各种药物对噻奈普汀与人血浆蛋白结合的影响。
The influence of various drugs on the binding of tianeptine to human plasma proteins.
作者信息
Zini R, Morin D, Salvadori C, Tillement J P
机构信息
Département Hospitalo-Universitaire de Pharmacologie, Créteil, France.
出版信息
Int J Clin Pharmacol Ther Toxicol. 1991 Feb;29(2):64-6.
PMID:2026465
Abstract
The plasma binding of the atypical tricyclic antidepressant tianeptine was studied in combination with six drugs, at therapeutic concentrations: cyamemazine, levomepromazine, flunitrazepam, oxazepam, diclofenac and salicylic acid. Of these drugs, only salicylic acid at high plasma concentrations impaired tianeptine binding and thus may potentiate its effects.
摘要
在治疗浓度下，研究了非典型三环类抗抑郁药噻奈普汀与六种药物（氰美马嗪、左美丙嗪、氟硝西泮、奥沙西泮、双氯芬酸和水杨酸）联合使用时的血浆蛋白结合情况。在这些药物中，只有高血浆浓度的水杨酸会损害噻奈普汀的结合，从而可能增强其作用。
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