Westarp M E, Hülser P J, Westphal K P, Wollinsky K H, Kornhuber H H
Ulm University Department of Neurology, Donau, Germany.
Int J Clin Pharmacol Ther Toxicol. 1991 Feb;29(2):71-4.
Systemic therapy of encephalitis with human interferon-beta regularly causes fever up to more than 41 degrees C. Patients often developed hematological changes, nausea and tachycardia. Analyzing the temperature curves of 13 patients with repeated intrathecal, lumbar instillations of 1.0 x 10(6) IU natural IFN-beta, we found markedly less drug-associated fever. Mean temperature was maximal at 38.7 degrees C 12 h after instillation; individual temperature did not exceed 39.7 degrees C, and was elevated for less than 36 h. Day-time of application did not change these results. After the first IFN-beta instillations, the mean integral of temperature vs time was twice as high as after subsequent applications. One and a half days after intrathecal administration and from 39 degrees C on, fever is independent from lumbar IFN-beta. Lower dosage, a more than ten-fold reduction of costs and less interference led us to prefer intrathecal interferon-beta applications. Given the data presented, we cannot yet evaluate clinical efficacy of intrathecal IFN-beta.
用人类β干扰素对脑炎进行全身治疗经常会导致体温高达41摄氏度以上。患者常出现血液学变化、恶心和心动过速。分析13例接受1.0×10(6)IU天然β干扰素反复鞘内、腰椎注入的患者的体温曲线，我们发现与药物相关的发热明显较少。注入后12小时平均体温最高为38.7摄氏度；个体体温未超过39.7摄氏度，且升高时间少于36小时。给药时间不影响这些结果。首次注入β干扰素后，体温与时间的平均积分是后续注入后的两倍。鞘内给药1.5天后且体温达到39摄氏度及以上时，发热与腰椎注入的β干扰素无关。较低的剂量、成本降低十多倍以及干扰较少，使我们更倾向于鞘内应用β干扰素。根据所提供的数据，我们尚无法评估鞘内β干扰素的临床疗效。
