Marova E I, Avakian M R, Podliashchuk E L, Sarkisian Iu Kh, Kallistova L P, Klimenko A A
Probl Endokrinol (Mosk). 1991 Jan-Feb;37(1):22-5.
A study was made of the condition of 44 acromegalic patients at various time after gamma-beam therapy. It has shown that therapeutic efficacy depends on initial sizes of adenomas and the level of growth hormone as well as on the time of observation. At late terms after therapy normalization of the level of growth hormone was observed in 41% of patients, clinical improvement in 44%, the absence of and effect in 15%. Radiation therapy resulted in a decrease in some hypophyseal functions in some of the patients and postradiation hyperprolactinemia in 56% of patients with the normal level of prolactin before therapy. The main shortcoming of radiation therapy was the length of time, necessary for achieving a therapeutic effect.
对44例肢端肥大症患者在γ射线治疗后的不同时间状况进行了研究。结果表明,治疗效果取决于腺瘤的初始大小、生长激素水平以及观察时间。治疗后期,41%的患者生长激素水平恢复正常,44%的患者临床症状改善,15%的患者无效果。放射治疗导致部分患者垂体功能有所下降,56%治疗前催乳素水平正常的患者出现放疗后高催乳素血症。放射治疗的主要缺点是达到治疗效果所需的时间较长。