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5-香叶氧基补骨脂素的光反应性及与DNA的无光反应

Photoreactivity of 5-geranoxypsoralen and lack of photoreaction with DNA.

作者信息

Morlière P, Bazin M, Dubertret L, Santus R, Sa E Melo T, Hüppe G, Haigle J, Forlot P, Bernard A

机构信息

Laboratoire de Dermatologie, INSERM U.312, Creteil, France.

出版信息

Photochem Photobiol. 1991 Jan;53(1):13-9. doi: 10.1111/j.1751-1097.1991.tb08461.x.

DOI:10.1111/j.1751-1097.1991.tb08461.x
PMID:2027902
Abstract

5-Geranoxypsoralen, commonly called bergamottin, a major furocoumarin contained in bergamot oil, is reported in vitro as a highly photoreactive psoralen. In ethanol, it exhibits quite a high triplet state quantum yield (approximately 0.37). The triplet state is involved in subsequent photochemistry which depends on the initial concentration and on the presence of oxygen. In contrast to most psoralens, absorption and fluorescence data suggest that 5-geranoxypsoralen does not interact with DNA in the dark. No UVA-induced interstrand cross-links in DNA were shown.

摘要

5-香叶氧基补骨脂素,通常称为佛手柑素,是佛手柑油中含有的一种主要呋喃香豆素,据体外研究报道,它是一种高光敏性补骨脂素。在乙醇中,它表现出相当高的三线态量子产率(约0.37)。三线态参与随后的光化学过程,这取决于初始浓度和氧气的存在。与大多数补骨脂素不同,吸收和荧光数据表明,5-香叶氧基补骨脂素在黑暗中不与DNA相互作用。未显示UVA诱导的DNA链间交联。

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