Barilla D E, Tolentino R, Kaplan R A, Pak C Y
Metabolism. 1978 Feb;27(2):125-31. doi: 10.1016/0026-0495(78)90158-0.
The effect of long-term thiazide therapy on the intestinal Ca absorption was measured in 10 well-defined cases of absorptive hypercalciuria with intestinal hyperabsorption of Ca and 8 with renal hypercalciuria ("renal leak" of Ca), many of whom had hyperabsorption of Ca. In most cases of absorptive hypercalciuria, the intestinal hyperabsorption of Ca persisted during treatment, despite restoration of normal urinary Ca. In contrast, the intestinal Ca absorption decreased significantly during thiazide therapy in 7 of 8 patients with renal hypercalciuria commensurate with the "correction" of the renal leak of Ca and secondary hyperparathyroidism. The results support the hypothesis that the intestinal hyperabsorption of Ca in absorptive hypercalciuria may be primary, whereas that in renal hypercalciuria may be associated with the hyperparathyroid state.
在10例明确诊断为伴有肠道钙吸收亢进的吸收性高钙尿症患者以及8例肾性高钙尿症（钙的“肾漏”）患者中测量了长期噻嗪类药物治疗对肠道钙吸收的影响，其中许多患者存在钙吸收亢进。在大多数吸收性高钙尿症病例中，尽管尿钙恢复正常，但治疗期间肠道钙吸收亢进仍持续存在。相比之下，8例肾性高钙尿症患者中有7例在噻嗪类药物治疗期间肠道钙吸收显著下降，这与钙的肾漏和继发性甲状旁腺功能亢进的“纠正”相一致。结果支持以下假设：吸收性高钙尿症中肠道钙吸收亢进可能是原发性的，而肾性高钙尿症中的肠道钙吸收亢进可能与甲状旁腺功能亢进状态有关。
