Rand R W
Neurosciences Institute, Hospital of the Good Samaritan, Los Angeles, California 90017-2395.
Surg Neurol. 1991 May;35(5):403-7. doi: 10.1016/0090-3019(91)90055-e.
A thrombogenic microballoon was developed to overcome the problems of cerebral aneurysm rupture during microballoon inflation and incomplete aneurysm obliteration by microballoons with subsequent fatal rupture. These complications occur in about 35% of reported series with current microballoon embolization techniques. The wall of the new thrombogenic microballoon allows 80% aneurysm occlusion by inflation, thus avoiding mechanical rupture, and at the same time it produces a blood clot in the space remaining between the microballoon and the aneurysm wall. This clot undergoes fibrosis with firm adherence of the microballoon to the aneurysm wall. Experimental evidence is presented to support these conclusions. This thrombogenic microballoon system is also applicable to carotid-cavernous fistulas and arteriovenous malformations.
一种促血栓形成微球囊被研发出来,以克服在微球囊充盈过程中脑动脉瘤破裂以及微球囊导致动脉瘤闭塞不完全继而发生致命性破裂的问题。在目前报道的采用微球囊栓塞技术的系列病例中,约35%会出现这些并发症。新型促血栓形成微球囊的囊壁通过充盈可使80%的动脉瘤闭塞,从而避免机械性破裂,同时在微球囊与动脉瘤壁之间剩余的空间内形成血凝块。该血凝块会发生纤维化,使微球囊牢固地附着于动脉瘤壁。文中提供了实验证据来支持这些结论。这种促血栓形成微球囊系统也适用于颈内动脉海绵窦瘘和动静脉畸形。