Plettenberg A, Janik I, Kolb H, Meigel W
Abteilung für Dermatologie, Allgemeinen Krankenhauses St. Georg, Hamburg.
Strahlenther Onkol. 1991 Apr;167(4):208-13.
In 23 patients with HIV-associated Kaposi's sarcoma 53 tumor lesions were treated with fractioned radiotherapy. Indication for the radiotherapy were mostly cosmetic reasons in stigmatizing tumors, but also in several cases pain, oedema or functional deficits as a result of the tumor lesions. 21 patients received orthovoltage irradiation, the remaining four patients were treated with telecobalt therapy. A complete response was observed in 17%, a partial response in 76% and unchanged lesions in 4%. In two cases (4%), both were treated with telecobalt-therapy by large tumor masses, there occurred a further tumor progression inspite of the radiotherapy. In ten lesions, all with partial remission, we later observed a repeated tumor progression. Important side effects were signs of inflammation as mucositis and edema or hyperpigmentation. The occurrence of acute side effects can be reduced by fractionating of the radiotherapy.
在23例与HIV相关的卡波西肉瘤患者中，对53个肿瘤病灶进行了分次放射治疗。放射治疗的指征主要是出于美容原因，针对有污名化作用的肿瘤，不过在某些情况下也是由于肿瘤病灶导致的疼痛、水肿或功能缺陷。21例患者接受了深部X线照射，其余4例患者接受了钴远距离治疗。观察到17%的患者完全缓解，76%的患者部分缓解，4%的患者病灶无变化。在2例（4%）患者中，二者均因肿瘤肿块较大接受了钴远距离治疗，尽管进行了放射治疗，但仍出现了进一步的肿瘤进展。在10个病灶中，所有病灶均部分缓解，后来我们观察到肿瘤复发进展。重要的副作用是炎症迹象，如粘膜炎、水肿或色素沉着。通过分次放射治疗可减少急性副作用的发生。
