Clorazepate: double blind crossover comparison of a single nightly dose with diazepam thrice daily in anxiety.
作者信息
Magnus R V, Dean B C, Curry S H
出版信息
Dis Nerv Syst. 1977 Oct;38(10):819-21.
PMID:20284
Abstract
In a double blind cross-over study in 40 patients with mild to moderate anxiety, clorazepate 15 mg at bedtime was as effective as diazepam on global rating and slightly superior on target symptom assessment. There was a significantly higher incidence and frequency of side effects during diazepam treatment. Occurrence of side effect related to plasma diazepam, and anxiolytic effect related to plasma nordiazepam. These results are discussed in relation to convenience of the single dose regimen and psychomotor performance.
摘要
相似文献
1
Clorazepate: double blind crossover comparison of a single nightly dose with diazepam thrice daily in anxiety.
Dis Nerv Syst. 1977 Oct;38(10):819-21.
2
3
A single-dose anti-anxiety drug. A report from the General Practitioner Research Group.
Practitioner. 1975 Jul;215(1285):98-101.
4
Value of a single night-time dose of potassium clorazepate in anxiety: a controlled trial comparison with diazepam.
Scott Med J. 1982 Oct;27(4):292-6. doi: 10.1177/003693308202700406.
5
Clorazepate dipotassium (Tranxene): a controlled evaluation in alcoholic patients after withdrawal.
Curr Ther Res Clin Exp. 1976 May;19(5):506-11.
6
Clinical trial of halazepam and clorazepate: considerations of a single bedtime dose [proceedings].
Psychopharmacol Bull. 1981 Jan;17(1):134-5.
7
8
Clinical and physiological assessment of chlorazepate, diazepam and placebo in anxious neurotics.
Int J Clin Pharmacol Biopharm. 1975 Jun;11(4):315-22.
9
A controlled comparative trial of clorazepate (Tranxene) and diazepam (Valium) for anxiety.
Med J Aust. 1977 Oct 15;2(16):525-8. doi: 10.5694/j.1326-5377.1977.tb114618.x.
10
Drug interactions in controlled clinical trials.
J Clin Psychiatry. 1982 Dec;43(12 Pt 2):95-9.
引用本文的文献
1
Duration of benzodiazepine clinical activity: lack of direct relationship with plasma half-life. A comparison of single vs divided dosage schedules of prazepam.
Psychopharmacology (Berl). 1984;84(3):293-8. doi: 10.1007/BF00555201.
Zotero 插件