Kawamura J, Meyer J S, Terayama Y, Weathers S
Cerebral Blood Flow Laboratory, Department of Veterans Affairs Medical Center, Houston, TX 77211.
Stroke. 1991 May;22(5):609-14. doi: 10.1161/01.str.22.5.609.
Leukoaraiosis quantified by computerized densitometric measurements of reduced Hounsfield numbers was correlated with local cerebral blood flow on the same computed tomographic images of 35 patients with multi-infarct dementia and 16 age-matched elderly normal volunteers. The ratio for area of frontal leukoaraiosis to total area of parenchyma among the patients was significantly greater than that among the normal volunteers (5.8 +/- 2.3% compared with 3.1 +/- 1.3%, p less than 0.001). Severity of leukoaraiosis around the frontal horns of the lateral ventricles correlated significantly with severity of leukoaraiosis of the centrum semiovale adjacent to the bodies of the lateral ventricles. Cerebral blood flow values for all representative cerebral regions except the parietal white matter were reduced among the patients compared with the normal volunteers. Multivariate regression analysis revealed that reduced cerebral perfusion in the putamen and thalamus correlated significantly with the severity of leukoaraiosis. Cerebral hypoperfusion in territories supplied by deep penetrating arteries may contribute to the pathogenesis of leukoaraiosis.
通过对35例多发梗死性痴呆患者和16例年龄匹配的老年正常志愿者的相同计算机断层扫描图像进行计算机密度测量，将Hounsfield值降低所量化的脑白质疏松与局部脑血流量进行关联。患者额叶脑白质疏松面积与实质总面积的比值显著高于正常志愿者（分别为5.8±2.3%和3.1±1.3%，p<0.001）。侧脑室额角周围脑白质疏松的严重程度与侧脑室体部相邻半卵圆中心脑白质疏松的严重程度显著相关。与正常志愿者相比，患者除顶叶白质外的所有代表性脑区的脑血流量值均降低。多变量回归分析显示，壳核和丘脑的脑灌注降低与脑白质疏松的严重程度显著相关。由深穿支动脉供血区域的脑灌注不足可能导致脑白质疏松的发病机制。
