老年性白内障患者晶状体、房水和血清中的总乳酸脱氢酶及其同工酶谱

Total lactate dehydrogenase and its isoenzyme pattern in lens, aqueous humour, and serum in cases of senile cataract.

作者信息

Nagpal R C, Singh R C, Singh G P, Ahluwalia B K

机构信息

Department of Ophthalmology, Medical College, Rohtak Haryana, India.

出版信息

Acta Ophthalmol (Copenh). 1991 Feb;69(1):57-60. doi: 10.1111/j.1755-3768.1991.tb01991.x.

DOI:10.1111/j.1755-3768.1991.tb01991.x

PMID:2028768

Abstract

Lens, aqueous humour and serum LDH and its isoenzyme pattern were estimated in 50 patients with senile cataract; 10 each with immature senile cortical cataract, mature senile cortical cataract, hypermature senile cortical cataract, immature senile nuclear cataract and mature senile nuclear cataract. The gradual decrease in total LDH and activity in the lens with advancement of cataract was maximum in hypermature senile cortical cataract. Aqueous LDH and its isoenzyme pattern remained unaltered with the maturity of cataract, and serum LDH and its isoenzyme pattern were found to be within normal limits. The lens LDH activity was found to be not related to the serum and aqueous humour LDH activity, but LDH3 isoenzyme showed declining trend, whereas LDH5 isoenzyme increased with the maturity of cataract. The present study concluded that significant decrease in lens LDH did not bear any relationship to LDH in serum and aqueous humour in cases of senile cataract.

摘要

对50例老年性白内障患者的晶状体、房水和血清乳酸脱氢酶（LDH）及其同工酶谱进行了测定；其中未成熟老年性皮质性白内障、成熟老年性皮质性白内障、过熟老年性皮质性白内障、未成熟老年性核性白内障和成熟老年性核性白内障患者各10例。随着白内障进展，晶状体中总LDH及其活性逐渐降低，在过熟老年性皮质性白内障中降低最为明显。房水LDH及其同工酶谱不随白内障成熟而改变，血清LDH及其同工酶谱在正常范围内。发现晶状体LDH活性与血清和房水LDH活性无关，但LDH3同工酶呈下降趋势，而LDH5同工酶随白内障成熟而增加。本研究得出结论，在老年性白内障病例中，晶状体LDH的显著降低与血清和房水中的LDH无任何关系。