Sforza E, Krieger J, Geisert J, Kurtz D
Service d'Explorations Fonctionnelles du Système Nerveux, Strasbourg, France.
Acta Paediatr Scand. 1991 Jan;80(1):80-5. doi: 10.1111/j.1651-2227.1991.tb11734.x.
This report describes the polysomnographic findings and the respiratory alterations during sleep in a 20-year-old patient with the Prader-Willi syndrome. Nocturnal recordings and a variant of the multiple sleep latency test showed excessive daytime sleepiness, sleep onset rapid eye movement episodes, snoring and sleep apnea. Treatment with nasal continuous positive airway pressure normalized the respiratory pattern and the sleep structure, except for rapid eye movement sleep onset. Whereas upper airway obstruction and obesity may explain the respiratory disorders, as shown by their resolution with continuous positive airway pressure treatment, hypothalamic dysfunction could play a role in the disruption of the normal nonrapid eye movement/rapid eye movement sleep periodicity.
本报告描述了一名患有普拉德-威利综合征的20岁患者睡眠期间的多导睡眠图检查结果及呼吸改变。夜间记录和多次睡眠潜伏期试验的一个变体显示该患者日间过度嗜睡、睡眠起始快速眼动期、打鼾及睡眠呼吸暂停。经鼻持续气道正压通气治疗使呼吸模式和睡眠结构恢复正常，但睡眠起始快速眼动期除外。上气道阻塞和肥胖可能解释呼吸障碍，持续气道正压通气治疗使其缓解即表明了这一点，而下丘脑功能障碍可能在正常非快速眼动/快速眼动睡眠周期的破坏中起作用。
