Vela-Bueno A, Kales A, Soldatos C R, Dobladez-Blanco B, Campos-Castello J, Espino-Hurtado P, Olivan-Palacios J
Arch Neurol. 1984 Mar;41(3):294-6. doi: 10.1001/archneur.1984.04050150072020.
Nine patients with the Prader-Willi syndrome, ranging in age from 3 to 21 years, were examined clinically as well as studied in the sleep laboratory. They had striking disturbances of sleep-wakefulness patterns. All patients except one had the symptom of excessive daytime sleepiness. The most striking finding was the presence in five patients of rapid-eye-movement (REM) sleep occurring at sleep onset (SOREM). None of the patients had the condition of sleep apnea. One patient, however, demonstrated severe hypoventilation during REM sleep; the lowest value recorded for O2 saturation was 40%, with a consistent value below 50% for as long as ten to 15 minutes. Previous findings have indicated that the Prader-Willi syndrome is of hypothalamic origin. We hypothesize that both the SOREM and O2 desaturation findings in our patients with the Prader-Willi syndrome are also a result of hypothalamic changes.
对9名年龄在3至21岁之间的普拉德-威利综合征患者进行了临床检查，并在睡眠实验室进行了研究。他们的睡眠-觉醒模式存在明显紊乱。除1名患者外，所有患者均有白天过度嗜睡症状。最显著的发现是5名患者在睡眠开始时出现快速眼动（REM）睡眠（睡眠起始快速眼动睡眠，SOREM）。所有患者均无睡眠呼吸暂停情况。然而，1名患者在REM睡眠期间出现严重通气不足；记录到的最低氧饱和度值为40%，在长达10至15分钟的时间内，氧饱和度持续低于50%。先前的研究结果表明，普拉德-威利综合征起源于下丘脑。我们推测，我们的普拉德-威利综合征患者出现的SOREM和氧饱和度降低现象也是下丘脑变化的结果。
