Sherman S, Troiano F P, Hawes R H, O'Connor K W, Lehman G A
Division of Gastroenterology/Hepatology, Indiana University Medical Center, Indianapolis.
Am J Gastroenterol. 1991 May;86(5):586-90.
Patients with pancreaticobiliary pain or idiopathic pancreatitis have been classified as having definitive (type I), presumptive (type II), or possible (type III) sphincter of Oddi dysfunction (SOD) based on clinical, laboratory, and ERCP data. This study was undertaken to determine the frequency of abnormal sphincter of Oddi manometry (SOM) when patients are classified by this system. Two hundred and thirteen patients with pancreaticobiliary pain were evaluated clinically; SOM, ERCP, and ductal contrast drainage time tests were performed. For biliary types I, II, and III, the frequency of abnormal SOM was 85.7%, 55.1%, and 28.1%, respectively. Similarly, for pancreatic types I, II, and III, an elevated basal sphincter pressure occurred in 92.3%, 58.2%, and 35.1%, respectively. When patients with an abnormal basal sphincter pressure were characterized by the magnitude of the elevation, the manometric profiles were similar for types I, II, and III. These data suggest that elevated sphincter pressure occurs more frequently in type III patients than previously reported, and supports consideration of SOM when evaluating and treating type II and type III patients.
根据临床、实验室及内镜逆行胰胆管造影（ERCP）数据，患有胰胆疼痛或特发性胰腺炎的患者已被分类为患有确定性（I型）、推定性（II型）或可能性（III型）Oddi括约肌功能障碍（SOD）。本研究旨在确定当患者按此系统分类时Oddi括约肌测压（SOM）异常的频率。对213例患有胰胆疼痛的患者进行了临床评估；进行了SOM、ERCP及导管造影引流时间测试。对于胆源性I型、II型和III型，SOM异常的频率分别为85.7%、55.1%和28.1%。同样，对于胰源性I型、II型和III型，基础括约肌压力升高分别发生在92.3%、58.2%和35.1% 的患者中。当以基础括约肌压力升高的幅度来表征基础括约肌压力异常患者时，I型、II型和III型的测压曲线相似。这些数据表明，III型患者中括约肌压力升高的发生率比先前报道的更高，并支持在评估和治疗II型和III型患者时考虑进行SOM检查。
