Rebel A, Basle M, Minard M F, Malkani K
Pathol Biol (Paris). 1977 Nov;25(9):611-6.
Comparison of biopsies from patients with Paget's bone disease before and during long-term treatment with calcitonin reveals that the ration of bone-adherent osteoclasts to free osteoclasts is not modified by the hormone. Nor does treatment alter the average number of nuclei in osteoclasts. Under electron microscopy, all the cytological anomalies of osteoclasts in Paget's bone disease and, in particular, the characteristic nuclear inclusions, persist through treatment. Thus, although such osteoclasts do react to calcitonin as demonstrated by several authors, the specific morphological anomalies remain unaffected by the treatment. It is likely that the osteoclast in Paget's bone disease is an abnormal cell with peculiarities which may be related to the yet unknown etiology of the disease.
对佩吉特骨病患者在长期使用降钙素治疗前和治疗期间的活检样本进行比较后发现，激素并未改变附着于骨的破骨细胞与游离破骨细胞的比例。治疗也未改变破骨细胞的平均核数。在电子显微镜下，佩吉特骨病中破骨细胞的所有细胞学异常，尤其是特征性的核内包涵体，在治疗过程中持续存在。因此，尽管如几位作者所证明的那样，此类破骨细胞确实对降钙素产生反应，但特定的形态学异常并未受到治疗的影响。佩吉特骨病中的破骨细胞很可能是一种异常细胞，其特性可能与该疾病尚未明确的病因有关。
