Basle M, Rebel A, Pouplard A, Filmon R, Lepatezour A
Nouv Presse Med. 1981 Apr 4;10(15):1193-7.
Despite considerable research work the cause of Paget's disease of bone remains uncertain. In a study of bone tissue from 100 patients with Paget's disease electron microscopy demonstrated alterations of the cells involved in bone remodelling. Osteoblasts showed distinct signs of hyperactivity, and the fibrillar arrangement of the osteoid tissue they produce was irregular. Osteoclasts were very large with numerous nuclei, and their bone-resorption activity was abnormal. Microcylindric inclusions visible in the cytoplasma and nuclei were morphologically comparable to the nucleocapsids of measles virus observed in experimental infections or in human pathology. Immunocytology tests confirmed the presence in osteoclasts of an antigenic material belonging to the measles virus group and cross-reacting with it. The hypothesis of a viral origin for Paget's disease of bone is supported by the chronic course of the condition, the histopathology of bone tissue, the ultrastructural changes in osteoclasts and the immunological results. A virus of the measles virus group probably plays a major role in the etiology of the disease.
尽管进行了大量研究工作，但骨佩吉特病的病因仍不明确。在一项对100例骨佩吉特病患者骨组织的研究中，电子显微镜显示参与骨重塑的细胞发生了改变。成骨细胞表现出明显的活跃迹象，它们产生的类骨质组织的纤维排列不规则。破骨细胞非常大，有许多细胞核，其骨吸收活性异常。在细胞质和细胞核中可见的微圆柱形内含物在形态上与实验感染或人类病理学中观察到的麻疹病毒核衣壳相似。免疫细胞学检测证实破骨细胞中存在属于麻疹病毒组并与之发生交叉反应的抗原物质。骨佩吉特病病毒起源的假说得到了该病慢性病程、骨组织组织病理学、破骨细胞超微结构变化以及免疫学结果的支持。麻疹病毒组的一种病毒可能在该病的病因中起主要作用。
