Rigg L A, Becker S G
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
Am J Perinatol. 1991 May;8(3):209-13. doi: 10.1055/s-2007-999379.
Umbilical cord blood erythrocyte insulin receptor characteristics of 13 normal and 14 diabetic pregnancies were evaluated to elucidate the effect of maternal diabetes on fetal insulin binding. Specific insulin binding to erythrocytes was similar in the two populations. However, in comparison to infants of nondiabetic women, infants of diabetic mothers exhibited a fourfold decrease in receptor affinity and a fourfold increased number of receptor sites in spite of significant hyperinsulinemia. The in utero infant of a diabetic mother therefore functions with a comparatively low affinity/high capacity insulin binding system that allows it to maintain normal insulin sensitivity in the presence of hyperinsulinemia. This altered, but balanced, mechanism may play an important role in glycemic homeostasis in utero and in the development of neonatal hypoglycemia.
对13例正常妊娠和14例糖尿病妊娠的脐带血红细胞胰岛素受体特征进行了评估，以阐明母体糖尿病对胎儿胰岛素结合的影响。两组人群中胰岛素与红细胞的特异性结合相似。然而，与非糖尿病女性的婴儿相比，糖尿病母亲的婴儿尽管存在明显的高胰岛素血症，但受体亲和力降低了四倍，受体位点数量增加了四倍。因此，糖尿病母亲的宫内婴儿具有相对低亲和力/高容量的胰岛素结合系统，这使其在高胰岛素血症情况下仍能维持正常的胰岛素敏感性。这种改变但平衡的机制可能在子宫内血糖稳态及新生儿低血糖的发生发展中起重要作用。
