[太平洋褶柔鱼胆碱酯酶的比较酶学研究]

[Comparative-enzymological study of cholinesterase of the Pacific squid Todarodes pacificus].

作者信息

Rozengart E V, Basova N E

出版信息

Zh Evol Biokhim Fiziol. 2010 Jan-Feb;46(1):3-16.

Abstract

Summarized are results of the 40-year studies of the Russian biochemists on the comparative-enzymological characteristics of cholinesterase of optic ganglia of the Pacific squid Todarodes pacificus. The review includes the comparative evaluation of the cholinesterase activity of various hydrobiont tissues, the proof of enzymatic homogeneity of the tissue of the Pacific squid optic ganglia, data on substrate specificity with study of 18 ester substrates as well as detailed study of inhibitory specificity (61 irreversible inhibitors and 49 reversible onium inhibitors). Peculiarity of properties of this enzyme as compared with vertebrate and invertebrate cholinesterases is shown.

摘要

总结了俄罗斯生物化学家对太平洋褶柔鱼（Todarodes pacificus）视神经节胆碱酯酶的比较酶学特性进行的40年研究结果。该综述包括对各种水生生物组织胆碱酯酶活性的比较评估、太平洋褶柔鱼视神经节组织酶同质性的证明、对18种酯底物进行研究所得的底物特异性数据以及对抑制特异性的详细研究（61种不可逆抑制剂和49种可逆鎓抑制剂）。展示了该酶与脊椎动物和无脊椎动物胆碱酯酶相比的特性。

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