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The in vitro metabolism of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) by dog adrenal mitochondria and metabolite covalent binding to mitochondrial macromolecules: a possible mechanism for the adrenocorticolytic effect.

作者信息

Martz F, Straw J A

出版信息

Drug Metab Dispos. 1977 Sep-Oct;5(5):482-6.

PMID:20298
Abstract
摘要

相似文献

1
The in vitro metabolism of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) by dog adrenal mitochondria and metabolite covalent binding to mitochondrial macromolecules: a possible mechanism for the adrenocorticolytic effect.
Drug Metab Dispos. 1977 Sep-Oct;5(5):482-6.
2
Metabolism and covalent binding of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p,'-DDD). Correlation between adrenocorticolytic activity and metabolic activation by adrenocortical mitochondria.1-（邻氯苯基）-1-（对氯苯基）-2,2-二氯乙烷（邻，对'-滴滴滴）的代谢与共价结合。肾上腺皮质线粒体的肾上腺皮质溶解活性与代谢活化之间的相关性。
Drug Metab Dispos. 1980 May-Jun;8(3):127-30.
3
Metabolic activation and binding of mitotane in adrenal cortex homogenates.
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In vitro biotransformations of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DD) and 1,1-bis(p-chlorophenyl)-2,2-dichloroethane (p,p'-DDD) by bovine adrenal.
J Agric Food Chem. 1975 Sep-Oct;23(5):996-9. doi: 10.1021/jf60201a006.
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Comparative CYP-dependent binding of the adrenocortical toxicants 3-methylsulfonyl-DDE and o,p'-DDD in Y-1 adrenal cells.肾上腺皮质毒物3-甲基磺酰基-DDE和邻，对'-滴滴滴在Y-1肾上腺细胞中细胞色素P450依赖性结合的比较
Arch Toxicol. 2007 Nov;81(11):793-801. doi: 10.1007/s00204-007-0206-5. Epub 2007 May 9.
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Treatment with o,p'-DDD (mitotane) decreased cytochrome P-450, heme, and microsomal protein content in the dog adrenal cortex in vivo.
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[The effect of o,p'-dichlorodiphenyldichloroethane on malic enzyme activity of the adrenal glands].[邻对二氯二苯二氯乙烷对肾上腺苹果酸酶活性的影响]
Vopr Med Khim. 1985 Jan-Feb;31(1):61-4.
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Metabolism of 1-(0-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) in rats.大鼠体内1-（邻氯苯基）-1-（对氯苯基）-2,2-二氯乙烷（邻，对'-滴滴滴）的代谢
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Bovine adrenal cortex transformations of mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; o,p'-DDD] and its p,p'- and m,p'-isomers.米托坦[1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷；邻，对'-滴滴滴]及其对，对'-和间，对'-异构体的牛肾上腺皮质转化
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[Action of chloditane on the phospholipid composition of the adrenals in dogs].[氯地坦对犬肾上腺磷脂成分的作用]
Farmakol Toksikol. 1983 Jul-Aug;46(4):65-8.

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