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在囊性纤维化中，用支气管镜给予重组人脱氧核糖核酸酶治疗肺叶肺不张？

Treatment of lobar atelectasis with bronchoscopically administered recombinant human deoxyribonuclease in cystic fibrosis?

作者信息

McLaughlin Anne Marie, McGrath Emmet, Barry Rupert, Egan Jim J, Gallagher Charles G

机构信息

Department of Medicine and Therapeutics, St Vincent's University Hospital, Dublin 4, Ireland.

出版信息

Clin Respir J. 2008 Apr;2(2):123-6. doi: 10.1111/j.1752-699X.2007.00024.x.

DOI:10.1111/j.1752-699X.2007.00024.x
PMID:20298317
Abstract

INTRODUCTION

Recombinant human deoxyribonuclease (rhDNase) reduces sputum viscosity and improves pulmonary function in cystic fibrosis (CF).

OBJECTIVE

The objective of this study was to describe our experience in which rhDNase (Pulmozyme; Roche, Basel, Switzerland) was administered by bronchoscopic instillation into atelectatic lobes in five adults with CF.

CONCLUSION

We found this method successful in treating lobar atelectasis, which was resistant to conventional therapy with antibiotics and physiotherapy. In all but one of the cases we described, administration of DNase in this manner resulted in a radiographic and clinical improvement of the atelectasis. We recommend that respiratory physicians consider this as a second line treatment in the management of atelectasis.

摘要

引言

重组人脱氧核糖核酸酶（rhDNase）可降低囊性纤维化（CF）患者痰液的黏稠度并改善肺功能。

目的

本研究的目的是描述我们对5例成年CF患者通过支气管镜将rhDNase（普米克令舒；罗氏公司，瑞士巴塞尔）注入肺不张肺叶的经验。

结论

我们发现这种方法成功地治疗了对常规抗生素和物理治疗耐药的肺叶肺不张。在我们描述的所有病例中，除1例之外，以这种方式给予脱氧核糖核酸酶均使肺不张在影像学和临床上得到改善。我们建议呼吸科医生将此作为肺不张治疗的二线方案。

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