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电凝法建立大脑中动脉永久性闭塞的体内磁共振成像评估：操作要点

In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure.

作者信息

Chauveau Fabien, Moucharrafie Samir, Wiart Marlène, Brisset Jean-Christophe, Berthezène Yves, Nighoghossian Norbert, Cho Tae-Hee

机构信息

CREATIS, CNRS UMR 5220, INSERM U 630, Université Claude Bernard Lyon I, France.

Cerebrovascular Unit, Hôpital Neurologique Pierre Wertheimer, Lyon, France.

出版信息

Exp Transl Stroke Med. 2010 Feb 4;2(1):4. doi: 10.1186/2040-7378-2-4.

DOI:10.1186/2040-7378-2-4
PMID:20298536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2827391/
Abstract

Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice using diffusion and T2-weighted MRI (7T) performed within 1 h and 24 h after surgery. Temporal muscle cauterization without MCA occlusion produced an early T2 hyperintensity mimicking an infarct. No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment.

摘要

通过电凝法造成永久性大脑中动脉（MCA）闭塞（pMCAO）是一种常用模型，但存在潜在的创伤性损伤。早期磁共振成像（MRI）监测可评估pMCAO导致的非特异性脑损伤。对22只瑞士小鼠采用pMCAO手术步骤，在术后1小时和24小时内进行扩散加权成像和T2加权MRI（7T），以评估创伤性脑损伤情况。未闭塞MCA仅烧灼颞肌会产生类似梗死的早期T2高信号。颞肌切开或开颅术后未见损伤。早期MRI监测有助于识别可能妨碍神经保护药物评估的非特异性脑损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/2827391/27401dbc05f8/2040-7378-2-4-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/2827391/22433064dec4/2040-7378-2-4-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/2827391/27401dbc05f8/2040-7378-2-4-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/2827391/22433064dec4/2040-7378-2-4-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/2827391/27401dbc05f8/2040-7378-2-4-2.jpg

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