Department of Biomolecular and Sport Sciences, Faculty of Health and Life Sciences, Coventry University, Cox St, Coventry CV1 5FB, UK.
Cell Immunol. 2010;263(1):22-30. doi: 10.1016/j.cellimm.2010.02.011. Epub 2010 Feb 24.
Psychological stress evokes rapid changes to the cardiovascular and neuroendocrine systems, responses that can become habituated following repeated exposure. This study, comprising of two phases, suggests that the immune system follows a similar trend. Phase 1: 15 healthy subjects (aged between 26 and 56years) provided capillary blood samples before and after completing three basic tasks using, in turn, two automotive touch screen interfaces (Interface 1-antecedent version, Interface 2-improved version). Using a chemiluminescent technique termed leukocyte coping capacity (LCC), the ability of leukocytes to produce reactive oxygen species in vitro was assessed. Significant differences in leukocyte activity were shown between treatment groups, where the greatest post-test decrease occurred after using Interface 1. Phase 2: a randomly selected sub-group (n=4) underwent weekly repeat testing using both interfaces. Significant differences in post-test leukocyte reactivity were exhibited between test weeks for each interface-the magnitude of response decreasing with successive exposure.
心理应激会引起心血管和神经内分泌系统的快速变化，这些反应在反复暴露后可能会变得习惯化。本研究分为两个阶段，表明免疫系统也遵循类似的趋势。第一阶段：15 名健康受试者（年龄在 26 至 56 岁之间）在使用两个汽车触摸屏界面（界面 1-先前段，界面 2-改进段）依次完成三项基本任务之前和之后提供毛细血管血样。使用一种称为白细胞应对能力（LCC）的化学发光技术，评估白细胞在体外产生活性氧的能力。白细胞活性在治疗组之间显示出显著差异，其中使用界面 1 后白细胞的活性下降最大。第二阶段：随机选择的亚组（n=4）每周使用两种界面重复测试。每个界面的测试后白细胞反应性在测试周之间显示出显著差异-随着连续暴露，反应幅度减小。
