Grunebaum E, Amir J, Merlob P, Mimouni M, Varsano I
Department of Paediatrics, Hasharon Hospital, Petah-Tiqva, Israel.
Eur J Pediatr. 1991 Feb;150(4):267-70. doi: 10.1007/BF01955528.
Jaundice associated with breast feeding is a frequent problem facing the paediatrician. Despite numerous reports on this subject, the natural history, familial occurrence and late neurodevelopment of children with breast milk jaundice remain unclear. The follow up of 60 infants with breast milk jaundice showed that there are two bilirubin peaks, on the 4th and 5th day and on the 14th-15th day of life. In the infants with uninterrupted breast feeding, the hyperbilirubinaemia disappeared slowly and could still be detected 12 weeks after birth. The familial incidence of 13.9%, indicating that in some cases a unique genetic factor is expressed. Late neurodevelopment or hearing defects were not observed, thus enabling the paediatrician to encourage continuation of breast feeding in most cases of healthy infants with breast milk jaundice.
母乳喂养相关的黄疸是儿科医生经常面临的问题。尽管关于这个主题有大量报道，但母乳性黄疸患儿的自然病程、家族发病率和后期神经发育情况仍不清楚。对60例母乳性黄疸婴儿的随访显示，胆红素出现两个峰值，分别在出生后第4和5天以及第14至15天。在持续母乳喂养的婴儿中，高胆红素血症消退缓慢，出生12周后仍可检测到。家族发病率为13.9%，表明在某些情况下存在独特的遗传因素。未观察到后期神经发育或听力缺陷，因此儿科医生能够鼓励大多数健康的母乳性黄疸婴儿继续母乳喂养。
