Wang Tang Chuan, Hua Chun Hun, Lin Ching Chia, Tsou Yung-An, Tseng Hsien Chang, Tsai Ming Hsui
Department of Otolaryngology Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jul;110(1):11-7. doi: 10.1016/j.tripleo.2009.11.035. Epub 2010 Mar 17.
Hard palatal cancer is relatively rare in the head and neck region. Treatment outcome, risk factors that lead to poor survival outcome, and treatment strategy are still controversial.
Retrospective study in a tertiary medical center.
Surgery is a better treatment strategy than concurrent chemoradiation therapy (CCRT) for achieving positive survival outcomes. We also found a higher surgical salvage rate in patients with hard palatal cancer who had local recurrence or neck relapse. Soft palate or infratemporal fossa involvement had poor outcomes. Ulcerative tumor features, tumor volumes larger than 10 mL, and local recurrent tumors that could not undergo salvage surgery also had poorer survival outcomes in our study.
Surgical management is still the first choice for patients with hard palate or alveolus squamous cell carcinomas even when patients had local or neck regional recurrence.
硬腭癌在头颈部相对少见。其治疗结果、导致生存结局不佳的危险因素及治疗策略仍存在争议。
在一家三级医疗中心进行的回顾性研究。
对于实现良好的生存结局，手术是比同步放化疗（CCRT）更好的治疗策略。我们还发现，硬腭癌局部复发或颈部复发患者的手术挽救率更高。软腭或颞下窝受累患者的结局较差。在我们的研究中，溃疡型肿瘤特征、肿瘤体积大于10 mL以及无法进行挽救性手术的局部复发性肿瘤患者的生存结局也较差。
即使患者出现局部或颈部区域复发，手术治疗仍是硬腭或牙槽鳞状细胞癌患者的首选。
