Baishya Nizara, Rahman Tashnin, Das Ashok Kumar, Kalita Chandi Ram, Sharma Jagannath Dev, Krishnatreya Manigreeva, Kataki Amal Chandra
Department of Head and Neck Surgery, Dr. B Borooah Cancer Institute, Guwahati, Assam, India.
Department of Hospital Based Cancer Registry, Dr. B Borooah Cancer Institute, Guwahati, Assam, India.
South Asian J Cancer. 2019 Jan-Mar;8(1):44-46. doi: 10.4103/sajc.sajc_66_18.
The main objective of this study was to analyze the clinical behavior and the impact of nodal metastasis on the prognosis of upper alveolus squamous cell carcinoma (SCC).
The medical records of 110 patients with SCC of the upper alveolus (International Classification of Diseases-10-C03.0) diagnosed during 2010-2015 were reviewed. Survival analysis was done using the Kaplan-Meier method and was compared using log rank-test. < 0.05 was considered statistically significant.
Of the 110 patients, 59 were males and 51 were females. Forty-six (41.8%) patients presented with lymph node metastasis. Fifty-three (51.8%) patients presented in Stage IVA, thirty (27.3%) patients in Stage IVB, ten (9.1%) patients in Stage III, 12 (10.9%) patients in Stage II. The 5-year overall survival (OS) was 71.1% in Stage II, in Stage III it was 65.6%, in Stage it was IVA 56.7%, and in Stage IVB it was 19.4% ( = 0.02). The 5-year OS for node negative compared with node positive was 66.3% versus 37.3%, respectively ( = 0.019).
Presence of lymph node metastasis is associated with lower survival rates. Adequate surgical resection with adjuvant treatment, where necessary, offers the best chance of disease control.
本研究的主要目的是分析上牙槽鳞状细胞癌（SCC）的临床行为以及淋巴结转移对其预后的影响。
回顾了2010年至2015年期间诊断为上牙槽SCC（国际疾病分类-10-C03.0）的110例患者的病历。采用Kaplan-Meier方法进行生存分析，并使用对数秩检验进行比较。P<0.05被认为具有统计学意义。
110例患者中，男性59例，女性51例。46例（41.8%）患者出现淋巴结转移。53例（51.8%）患者为IVA期，30例（27.3%）患者为IVB期，10例（9.1%）患者为III期，12例（10.9%）患者为II期。II期患者的5年总生存率（OS）为71.1%，III期为65.6%，IVA期为56.7%，IVB期为19.4%（P = 0.02）。淋巴结阴性患者与阳性患者的5年OS分别为66.3%和37.3%（P = 0.019）。
淋巴结转移的存在与较低的生存率相关。必要时进行充分的手术切除并辅以治疗，可提供最佳的疾病控制机会。
