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心脏手术期间的医源性A型主动脉夹层

Iatrogenic type A aortic dissection during cardiac surgery.

作者信息

Hwang Ho Young, Jeong Dong Seop, Kim Kyung-Hwan, Kim Ki-Bong, Ahn Hyuk

机构信息

Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-744, South Korea.

出版信息

Interact Cardiovasc Thorac Surg. 2010 Jun;10(6):896-9. doi: 10.1510/icvts.2009.231001. Epub 2010 Mar 18.

Abstract

We reviewed our experience of intraoperative type A aortic dissection during cardiovascular surgery. From January 1998 to May 2009, intraoperative aortic dissection occurred in 10 of 3421 cardiac surgical patients (M:F=4:6, 62.4+/-8.0 years). Preoperative diagnoses were valvular heart disease (n=6), ischemic heart disease (n=2), combined disease (n=1) and aortic aneurysm (n=1). All underwent total circulatory arrest (TCA) with retrograde cerebral perfusion and the torn aorta was replaced (n=8) or repaired (n=2). Iatrogenic type A dissection occurred in 0.29% of patients. It was related with cannulation of ascending aorta (n=4), axillary artery (n=2), aortic root (n=2), and femoral artery (n=1) and aortotomy repair (n=1). Mortality rate was 40% (4/10). After adoption of routine intraoperative transesophageal echocardiography, mortality rate decreased from 75% (3/4) to 17% (1/6) (P=0.190). We initiated TCA before achieving deep hypothermia in three of four non-survivors. There was a trend of increased mortality when the disease extended beyond aortic arch (67%, 4/6 vs. 0%, 0/4; P=0.076). Although intraoperative aortic dissection occurred in <0.3% of our patient population, mortality was high, especially when it extended beyond the arch vessels. Better results were expected when early recognition and proper treatment under deep hypothermic circulatory arrest could be performed.

摘要

我们回顾了心血管手术中A型主动脉夹层的治疗经验。1998年1月至2009年5月,3421例心脏手术患者中有10例发生术中主动脉夹层(男:女=4:6,年龄62.4±8.0岁)。术前诊断为瓣膜性心脏病(n=6)、缺血性心脏病(n=2)、合并疾病(n=1)和主动脉瘤(n=1)。所有患者均接受了全身循环停搏(TCA)及逆行脑灌注,撕裂的主动脉被置换(n=8)或修复(n=2)。医源性A型夹层发生在0.29%的患者中。其与升主动脉插管(n=4)、腋动脉插管(n=2)、主动脉根部插管(n=2)、股动脉插管(n=1)及主动脉切开修复(n=1)有关。死亡率为40%(4/10)。采用常规术中经食管超声心动图后,死亡率从75%(3/4)降至17%(1/6)(P=0.190)。4例非幸存者中有3例在体温未降至深低温前就开始了TCA。当病变累及主动脉弓以外时,死亡率有升高趋势(67%,4/6 vs. 0%,0/4;P=0.076)。虽然术中主动脉夹层在我们的患者群体中发生率<0.3%,但死亡率很高,尤其是当病变累及弓上血管时。若能在深低温循环停搏下早期识别并进行恰当治疗,则有望取得更好的结果。

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