Department of Internal Medicine, University of Turin, Torino, Italy.
Diabetes Care. 2010 Jun;33(6):1233-5. doi: 10.2337/dc09-1690. Epub 2010 Mar 18.
To assess whether TCF7L2 polymorphism has a role in the deterioration of glycemic control.
Metabolic variables were evaluated at baseline and after 6-year follow-up in 1,480 Caucasian subjects from a population-based cohort.
At baseline, T-allele carriers showed significantly lower BMI and homeostasis model assessment for beta-cell function (HOMA-B) values and higher fasting glycemia and diabetes prevalence. At follow-up, fasting glucose and HOMA-B index were increased and reduced, respectively, in carriers of the T-allele. Incident impaired fasting glucose (IFG) and incident diabetes were 5.7, 10.7, 16.9% and 1.6, 1.7, 3.0% in the CC, CT, and TT genotypes, respectively. In a multiple logistic regression model, the association between incident IFG and the T-allele was significant (odds ratio [OR] 2.08 [95% CI 1.35-3.20] and 3.56 [2.11-5.98] in CT and TT genotypes, respectively).
The T-allele of TCF7L2 rs7903146 polymorphism was independently associated with increasing fasting glucose values toward hyperglycemia in the follow-up.
评估 TCF7L2 多态性是否与血糖控制恶化有关。
在一项基于人群的队列中，对 1480 名白种人受试者进行了基线和 6 年随访时的代谢变量评估。
在基线时，T 等位基因携带者的 BMI 和稳态模型评估的胰岛β细胞功能（HOMA-B）值明显较低，空腹血糖和糖尿病患病率较高。在随访期间，T 等位基因携带者的空腹血糖和 HOMA-B 指数分别升高和降低。IFG 和糖尿病的发生率分别为 CC、CT 和 TT 基因型的 5.7%、10.7%、16.9%和 1.6%、1.7%、3.0%。在多元逻辑回归模型中，IFG 与 T 等位基因之间存在显著关联（CT 和 TT 基因型的比值比分别为 2.08[95%可信区间 1.35-3.20]和 3.56[2.11-5.98]）。
TCF7L2 rs7903146 多态性的 T 等位基因与随访期间空腹血糖值向高血糖的升高独立相关。
