Uncomplicated (Pure) Hereditary Spastic Paraplegia Overview

The purpose of this overview is to: 1.. Briefly describe the clinical characteristics of uncomplicated (pure) hereditary spastic paraplegia; 2.. Review the genetic causes of uncomplicated hereditary spastic paraplegia; 3.. Review the differential diagnosis of uncomplicated hereditary spastic paraplegia, which includes complicated hereditary spastic paraplegia with a focus on treatable genetic disorders; 4.. Provide an evaluation strategy to identify the genetic cause of uncomplicated hereditary spastic paraplegia in a proband (when possible); 5.. Review management of uncomplicated hereditary spastic paraplegia; 6.. Inform genetic counseling of family members of an individual with uncomplicated hereditary spastic paraplegia.