Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
J Am Chem Soc. 2010 Apr 14;132(14):5010-1. doi: 10.1021/ja1017046.
A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary alpha-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile beta,gamma-unsaturated ketones with good enantioselectivity.
一种新的有机金属化合物家族,有机锆试剂,被证明是(活化)次级烷基亲电试剂交叉偶联反应的合适伙伴。因此,开发了第一种与烯基金属试剂偶联次级α-溴代酮的催化方法,具体而言,是一种温和、通用且立体转化的碳-碳键形成过程,可生成具有良好对映选择性的潜在不稳定的β,γ-不饱和酮。