Smith Sean W, Fu Gregory C
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
J Am Chem Soc. 2008 Sep 24;130(38):12645-7. doi: 10.1021/ja805165y. Epub 2008 Sep 3.
A stereoconvergent method for the catalytic asymmetric Negishi cross-coupling of racemic secondary propargylic halides with arylzinc reagents has been developed. Neither family of compounds has previously been shown to be a suitable partner in such coupling processes. From a practical point of view, it is noteworthy that the catalyst components (NiCl2.glyme and pybox ligand 1) are commercially available.
已开发出一种立体收敛方法，用于外消旋仲炔丙基卤化物与芳基锌试剂的催化不对称Negishi交叉偶联反应。此前尚未证明这两类化合物在此类偶联反应中是合适的反应伙伴。从实际角度来看，值得注意的是催化剂组分（NiCl2·甘醇二甲醚和吡唑啉酮配体1）可从商业渠道购得。
