衰老、环境抗原和饮食限制对无菌和普通Lobund-Wistar大鼠淋巴细胞亚群表达的影响。

Influence of aging, environmental antigens, and dietary restriction on expression of lymphocyte subsets in germ-free and conventional Lobund-Wistar rats.

作者信息

Gilman-Sachs A, Kim Y B, Pollard M, Snyder D L

机构信息

Department of Microbiology and Immunology, University of Health Sciences, Chicago Medical School.

出版信息

J Gerontol. 1991 May;46(3):B101-6. doi: 10.1093/geronj/46.3.b101.

DOI:10.1093/geronj/46.3.b101

PMID:2030264

Abstract

Lymphocyte subsets from four groups of Lobund-Wistar (L-W) rats were quantitated to determine the influence of diet restriction (DR) and exposure to environmental antigens on the development of these cells. The following effects were found from 6 to 30 months of age: The number of Ts/c and Ts cells were higher in germ-free (GF) vs conventional (CV) rats, whereas B-cell numbers were lower. W3/13 T cells, Ts, and NK cell numbers were higher in DR vs full-fed rats, whereas B-cell numbers were lower. OX19 and W3/13 T cell numbers decreased from 6 months to 30 months in each group, whereas NK cell numbers increased. Also, OX6+ B cell numbers increased with age, and Ts/c numbers decreased. These data may reflect a relationship between enhanced T-cell function and the extended life span and lower tumor incidence observed in DR L-W rats.

摘要

对四组洛本德-威斯塔（L-W）大鼠的淋巴细胞亚群进行定量分析，以确定饮食限制（DR）和暴露于环境抗原对这些细胞发育的影响。在6至30个月龄时发现了以下效应：无菌（GF）大鼠的抑制性T细胞/细胞毒性T细胞（Ts/c）和抑制性T细胞（Ts）数量高于普通（CV）大鼠，而B细胞数量则较低。与全喂饲大鼠相比，DR大鼠的W3/13 T细胞、Ts细胞和自然杀伤（NK）细胞数量更高，而B细胞数量更低。每组中OX19和W3/13 T细胞数量从6个月到30个月减少，而NK细胞数量增加。此外，OX6+B细胞数量随年龄增加，Ts/c数量减少。这些数据可能反映了DR L-W大鼠中增强的T细胞功能与延长的寿命和较低的肿瘤发生率之间的关系。