Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
J Urol. 2010 May;183(5):1880-4. doi: 10.1016/j.juro.2010.01.029. Epub 2010 Mar 29.
Buccal derived graft tissue has been proven to be useful in urethral reconstruction. However, nonbuccal sources are often needed for long segment strictures or for those with prior buccal harvest. We describe a technique using full-thickness abdominal skin grafts for long segment urethroplasty and present the short-term outcomes.
A total of 21 men underwent urethroplasty for strictures of an average of 11 cm (range 4 to 24) using abdominal wall skin. Prior urethroplasty was performed in 52% of patients and multistage repair was conducted in 48%.
The recurrence rate following urethroplasty was 19%, with 9.5% requiring revision after first stage urethroplasty. Complications included hair from the skin graft during the early part of the series (14.5%), glans dehiscence (9.5%), urethrocutaneous fistula (9.5%) and periurethral abscess (1 patient). Histological evaluation at 6 months demonstrated excellent uptake of grafts with minimal keratinization.
In men with significant penile scarring, lichen sclerosis and long segment urethral strictures the use of abdominal skin limits donor site morbidity, and provides a useful alternative graft source for urethroplasty when buccal mucosa or genital skin are not available or sufficient. Grafts should be harvested from nonhair bearing areas to minimize the risk of urethral hair development.
颊黏膜衍生移植物组织已被证明在尿道重建中有用。然而,对于长段狭窄或有颊黏膜采集史的患者,通常需要非颊黏膜来源。我们描述了一种使用全厚腹壁皮片进行长段尿道成形术的技术,并介绍了短期结果。
共有 21 名男性因平均 11 厘米(范围 4 至 24)的狭窄接受了尿道成形术,使用腹壁皮肤。52%的患者有先前的尿道成形术史,48%的患者进行了多阶段修复。
尿道成形术后的复发率为 19%,9.5%的患者在第一阶段尿道成形术后需要再次修复。并发症包括早期皮片移植中出现的毛发(14.5%)、龟头裂开(9.5%)、尿道皮肤瘘(9.5%)和尿道周围脓肿(1 例)。6 个月的组织学评估显示移植物吸收良好,角化程度最小。
对于阴茎严重瘢痕、硬化性苔藓和长段尿道狭窄的男性,使用腹部皮肤可减少供区并发症,当颊黏膜或生殖器皮肤不可用或不足时,为尿道成形术提供了一种有用的替代移植物来源。皮片应取自无毛发区,以最大程度降低尿道毛发发育的风险。