男性生殖器硬化性苔藓
Male genital lichen sclerosus.
作者信息
Bunker Christopher Barry, Shim Tang Ngee
机构信息
Department of Dermatology, University College Hospital, London.
出版信息
Indian J Dermatol. 2015 Mar-Apr;60(2):111-7. doi: 10.4103/0019-5154.152501.
Abstract
Male genital lichen sclerosus (MGLSc) is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. An afeared complication is squamous cell carcinoma (SCC) of the penis. The precise etiopathogenesis of MGLSc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (HPV) hepatitis C (HCV), Epstein-Barr virus (EBV) and Borrelia) factors have been implicated: Consideration of all the evidence suggests that chronic exposure of susceptible epithelium to urinary occlusion by the foreskin seems the most likely pathomechanism. The mainstay of treatment is topical ultrapotent corticosteroid therapy. Surgery is indicated for cases unresponsive to topical corticosteroid therapy, phimosis, meatal stenosis, urethral stricture, carcinoma in situ (CIS) and squamous cell carcinoma.
摘要
男性硬化性苔藓（MGLSc）是一种慢性炎症性皮肤病，可导致男性性交困难和泌尿系统疾病。一种令人担忧的并发症是阴茎鳞状细胞癌（SCC）。尽管遗传、自身免疫和感染（如人乳头瘤病毒（HPV）、丙型肝炎病毒（HCV）、爱泼斯坦-巴尔病毒（EBV）和疏螺旋体）因素被认为与MGLSc有关，但其确切的发病机制仍存在争议：综合所有证据表明，易感上皮长期暴露于包皮引起的尿路梗阻似乎是最可能的发病机制。治疗的主要方法是外用超强效皮质类固醇疗法。对于局部皮质类固醇治疗无反应、包茎、尿道口狭窄、尿道狭窄、原位癌（CIS）和鳞状细胞癌的病例，建议进行手术治疗。
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Primary Melanoma of the Penis in 3 Patients With Lichen Sclerosus.3例患有硬化性苔藓的阴茎原发性黑色素瘤
JAMA Dermatol. 2016 Feb;152(2):226-7. doi: 10.1001/jamadermatol.2015.3404.
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Circulating anti-BP180 NC16a and anti-BP230 autoantibodies in patients with genital lichen sclerosus do not correlate with disease activity and pruritus.生殖器硬化性苔藓患者体内循环抗BP180 NC16a和抗BP230自身抗体与疾病活动度及瘙痒无关。
Acta Derm Venereol. 2014 Nov;94(6):711-2. doi: 10.2340/00015555-1851.
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The clinical spectrum of lichen sclerosus in male patients - a retrospective study.男性患者硬化性苔藓的临床谱——一项回顾性研究。
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The contribution of drugs to lichen sclerosus.药物对地衣状硬化苔藓的影响。
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