酸性钙库开门营业：拓展细胞内 Ca2+信号转导的潜能。
Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.
机构信息
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
出版信息
Trends Cell Biol. 2010 May;20(5):277-86. doi: 10.1016/j.tcb.2010.02.003. Epub 2010 Mar 18.
Abstract
Changes in cytosolic calcium concentration are crucial for a variety of cellular processes in all cells. It has long been appreciated that calcium is stored and released from intracellular calcium stores such as the endoplasmic reticulum. However, emerging evidence indicates that calcium is also dynamically regulated by a seemingly disparate collection of acidic organelles. In this paper, we review the defining features of these 'acidic calcium stores' and highlight recent progress in understanding the mechanisms of uptake and release of calcium from these stores. We also examine the nature of calcium buffering within the stores, and summarize the physiological and pathophysiological significance of these ubiquitous organelles in calcium signaling.
摘要
细胞质钙离子浓度的变化对于所有细胞的各种细胞过程都至关重要。长期以来，人们一直认为钙离子是从细胞内的钙库（如内质网）中储存和释放的。然而，新出现的证据表明，钙离子也被一系列看似不同的酸性细胞器动态调节。在本文中，我们回顾了这些“酸性钙库”的特征，并强调了最近在理解这些钙库中钙摄取和释放机制方面的进展。我们还研究了钙库内钙缓冲的性质，并总结了这些普遍存在的细胞器在钙信号转导中的生理和病理生理学意义。
相似文献
1
Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.酸性钙库开门营业：拓展细胞内 Ca2+信号转导的潜能。
Trends Cell Biol. 2010 May;20(5):277-86. doi: 10.1016/j.tcb.2010.02.003. Epub 2010 Mar 18.
2
Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets.由人血小板中的钙离子和液泡型氢离子-ATP酶介导的钙离子向酸性细胞器的积累。
Biochem J. 2005 Aug 15;390(Pt 1):243-52. doi: 10.1042/BJ20050168.
3
Role of proton gradients and vacuola H(+)-ATPases in the refilling of intracellular calcium stores in exocrine cells.质子梯度和液泡H(+) -ATP酶在外分泌细胞内钙库再充盈中的作用
Curr Biol. 2000 Feb 10;10(3):161-4. doi: 10.1016/s0960-9822(00)00313-4.
4
Acidic Ca(2+) stores in platelets.血小板中的酸性 Ca(2+) 储存库。
Cell Calcium. 2011 Aug;50(2):168-74. doi: 10.1016/j.ceca.2010.11.011. Epub 2010 Dec 17.
5
Functional characterization of thapsigargin and agonist-insensitive acidic Ca2+ stores in Drosophila melanogaster S2 cell lines.毒胡萝卜素和激动剂不敏感酸性钙库在黑腹果蝇S2细胞系中的功能特性
Cell Calcium. 1999 Jun;25(6):429-38. doi: 10.1054/ceca.1999.0043.
6
Acidic Ca(2+) stores come to the fore.酸性钙库开始发挥重要作用。
Cell Calcium. 2011 Aug;50(2):109-12. doi: 10.1016/j.ceca.2011.03.009. Epub 2011 Apr 16.
7
NAADP induces pH changes in the lumen of acidic Ca2+ stores.烟酰胺腺嘌呤二核苷酸磷酸（NAADP）可诱导酸性钙库内腔的pH值发生变化。
Biochem J. 2007 Mar 1;402(2):301-10. doi: 10.1042/BJ20060759.
8
Role of acidic stores in secretory epithelia.酸性储存库在分泌上皮中的作用。
Cell Calcium. 2014 Jun;55(6):346-54. doi: 10.1016/j.ceca.2014.04.002. Epub 2014 Apr 18.
9
Vacuolar Ca(2+) uptake.液泡钙离子摄取。
Cell Calcium. 2011 Aug;50(2):139-46. doi: 10.1016/j.ceca.2011.01.004. Epub 2011 Feb 9.
10
STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets.钙库耗竭时，STIM1 和 STIM2 位于酸性 Ca2+ 库中，并与 Orai1 结合。
J Biol Chem. 2011 Apr 8;286(14):12257-70. doi: 10.1074/jbc.M110.190694. Epub 2011 Feb 14.
引用本文的文献
1
The adhesion plaque mediates fluid discharge and duplication of the contractile vacuole complex in Trypanosoma cruzi.黏着斑介导克氏锥虫中收缩泡复合体的液体排出和复制。
J Cell Sci. 2025 Jul 3. doi: 10.1242/jcs.263810.
2
Lysosome and plasma membrane Piezo channels of Trypanosoma cruzi are essential for proliferation, differentiation and infectivity.克氏锥虫的溶酶体和质膜Piezo通道对其增殖、分化和感染性至关重要。
PLoS Pathog. 2025 Apr 23;21(4):e1013105. doi: 10.1371/journal.ppat.1013105. eCollection 2025 Apr.
3
Chemigenetic Ca2+ indicators report elevated Ca2+ levels in endothelial Weibel-Palade bodies.化学遗传钙离子指示剂显示内皮细胞Weibel-Palade小体中的钙离子水平升高。
PLoS One. 2025 Jan 27;20(1):e0316854. doi: 10.1371/journal.pone.0316854. eCollection 2025.
4
Heterogating Gel Iontronics: A Revolution in Biointerfaces and Ion Signal Transmission.异质门控凝胶离子电子学：生物界面与离子信号传输的一场革命。
Gels. 2024 Sep 15;10(9):594. doi: 10.3390/gels10090594.
5
Calcium Deregulation in Neurodegeneration and Neuroinflammation in Parkinson's Disease: Role of Calcium-Storing Organelles and Sodium-Calcium Exchanger.钙失衡与帕金森病神经炎症和神经退行性变：钙储存细胞器和钠钙交换体的作用。
Cells. 2024 Aug 4;13(15):1301. doi: 10.3390/cells13151301.
6
Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels.选择性过滤器的可塑性对于溶酶体 TPC2 通道的渗透至关重要。
Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2320153121. doi: 10.1073/pnas.2320153121. Epub 2024 Jul 29.
7
Endolysosomal transient receptor potential mucolipins and two-pore channels: implications for cancer immunity.溶酶体瞬时受体电位黏蛋白和双孔通道：对癌症免疫的影响。
Front Immunol. 2024 May 22;15:1389194. doi: 10.3389/fimmu.2024.1389194. eCollection 2024.
8
Endoplasmic Reticulum Dysfunction: An Emerging Mechanism of Vitiligo Pathogenesis.内质网功能障碍：白癜风发病机制的新机制
Clin Cosmet Investig Dermatol. 2024 May 17;17:1133-1144. doi: 10.2147/CCID.S459070. eCollection 2024.
9
TASL mediates keratinocyte differentiation by regulating intracellular calcium levels and lysosomal function.TASL 通过调节细胞内钙离子水平和溶酶体功能来介导角质形成细胞分化。
Sci Rep. 2024 May 14;14(1):10978. doi: 10.1038/s41598-024-61674-3.
10
Oral Release Kinetics, Biodistribution, and Excretion of Dopants from Barium-Containing Bioactive Glass in Rats.含钡生物活性玻璃中掺杂剂在大鼠体内的口服释放动力学、生物分布及排泄情况
ACS Omega. 2024 Jan 31;9(6):7188-7205. doi: 10.1021/acsomega.3c09250. eCollection 2024 Feb 13.
本文引用的文献
1
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles.一个祖先后口动物双孔通道家族介导烟酰胺腺嘌呤二核苷酸磷酸依赖性酸性细胞器内钙释放。
J Biol Chem. 2010 Jan 29;285(5):2897-901. doi: 10.1074/jbc.C109.081943. Epub 2009 Nov 25.
2
In with the TRP channels: intracellular functions for TRPM1 and TRPM2.TRP 通道的新成员：TRPM1 和 TRPM2 的细胞内功能。
Sci Signal. 2009 Nov 3;2(95):pe69. doi: 10.1126/scisignal.295pe69.
3
Secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine cells.神经内分泌细胞细胞质中肌醇 1,4,5-三磷酸依赖的 Ca2+信号转导中的分泌颗粒。
FASEB J. 2010 Mar;24(3):653-64. doi: 10.1096/fj.09-132456. Epub 2009 Oct 16.
4
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.双孔通道1在NAADP介导的钙信号传导中的基本要求。
J Cell Biol. 2009 Jul 27;186(2):201-9. doi: 10.1083/jcb.200904073. Epub 2009 Jul 20.
5
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.双孔通道 TPCN2 介导 NAADP 依赖性溶酶体储存钙释放。
Pflugers Arch. 2009 Sep;458(5):891-9. doi: 10.1007/s00424-009-0690-y. Epub 2009 Jun 26.
6
Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate.谷氨酸对NAADP敏感的酸性钙库的募集作用。
Biochem J. 2009 Aug 27;422(3):503-12. doi: 10.1042/BJ20090194.
7
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.酒精代谢产物对胰腺蛋白酶的激活作用依赖于通过酸性储存肌醇三磷酸受体释放钙离子。
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10758-63. doi: 10.1073/pnas.0904818106. Epub 2009 Jun 15.
8
The role of acidocalcisomes in parasitic protists.酸性钙小体在寄生原生生物中的作用。
J Eukaryot Microbiol. 2009 May-Jun;56(3):208-13. doi: 10.1111/j.1550-7408.2009.00404.x.
9
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.瞬时受体电位阳离子通道亚家族M成员2（TRPM2）在β细胞中作为溶酶体钙释放通道发挥作用。
Sci Signal. 2009 May 19;2(71):ra23. doi: 10.1126/scisignal.2000278.
10
NAADP mobilizes calcium from acidic organelles through two-pore channels.烟酰胺腺嘌呤二核苷酸磷酸（NAADP）通过双孔通道从酸性细胞器中动员钙。
Nature. 2009 May 28;459(7246):596-600. doi: 10.1038/nature08030. Epub 2009 Apr 22.
Zotero 插件