Department Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Hum Immunol. 2010 Jun;71(6):598-601. doi: 10.1016/j.humimm.2010.03.002. Epub 2010 Apr 1.
To date, seven studies have provided evidence for an association between the gene encoding for myosin IXB (MYO9B) and celiac disease (CD), and inflammatory bowel diseases, including single nucleotide polymorphisms (SNPs) rs2305767, rs1457092, and rs2305764. We investigated whether MYO9B is associated with T1D. The three SNPs were genotyped in Dutch samples from 288 T1D patients and 1615 controls. The A allele of SNP rs2305767A>G showed some evidence of association with T1D (nominal p for genotype = 0.06; OR carrier = 1.51, 95% CI = 1.04-2.19), but not in British samples from 4301 case patients and 4706 controls (p = 0.53), or when the Dutch and UK data were pooled (N patients = 4582, N controls= 6224; Mantel-Hansel p = 0.83). Furthermore, the nonsynonymous rs1545620 C>A SNP that has been associated with the inflammatory bowel disease, showed no association with T1D in British case-control set (p = 0.57). We conclude that MYO9B might not be a strong determinant of T1D, although there was some association in our initial Dutch study. Further studies are needed to evaluate the role of MYO9B in T1D.
迄今为止，已有七项研究为肌球蛋白 IXB（MYO9B）基因与乳糜泻（CD）和炎症性肠病之间的关联提供了证据，包括单核苷酸多态性（SNP）rs2305767、rs1457092 和 rs2305764。我们研究了 MYO9B 是否与 T1D 有关。在来自 288 名 T1D 患者和 1615 名对照的荷兰样本中，对这三个 SNP 进行了基因分型。SNP rs2305767A>G 的 A 等位基因与 T1D 有一定的关联（基因型名义 p = 0.06；OR 携带者= 1.51，95%CI = 1.04-2.19），但在来自 4301 名病例患者和 4706 名对照的英国样本中（p = 0.53）或当荷兰和英国的数据合并时（N 患者= 4582，N 对照= 6224；Mantel-Hansel p = 0.83）均无关联。此外，与炎症性肠病相关的非同义 rs1545620 C>A SNP 与英国病例对照集的 T1D 无关（p = 0.57）。我们的结论是，虽然在我们最初的荷兰研究中存在一些关联，但 MYO9B 可能不是 T1D 的一个强决定因素。需要进一步研究来评估 MYO9B 在 T1D 中的作用。
