The Gynecologic Clinic, The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Gynecol Oncol. 2010 Jun;117(3):446-50. doi: 10.1016/j.ygyno.2010.02.023. Epub 2010 Mar 21.
The association between tetranectin (TN) and selected lifestyle factors (smoking and alcohol) and the postoperative complication rate for ovarian cancer (OC) patients undergoing primary cytoreductive surgery has not yet been characterized. The aim of the study was to examine the value of TN, smoking and alcohol as indicators of postoperative complications in OC patients.
Serum TN was measured for 374 OC patients undergoing primary cytoreductive surgery. In addition, they reported their smoking and alcohol status. The prognostic value of variables was found with univariate and multivariate analyses using logistic regression analysis.
In univariate analysis TN was the only one out of 8 variables that significantly predicted postoperative complications (OR=0.55 (95% CI: 0.34-0.87), P=0.01). High preoperative serum TN was associated with a low risk of postoperative complications. Stepwise reduction of the multivariate model demonstrated that TN and histology were the only significant co-variables (TN, OR=0.51 (95% CI: 0.32-0.83), P=0.006; histology, OR=1.70 (95% CI: 1.02-2.82), P=0.041). TN was the only indicator, which was statistical significant in both univariate and multivariate analyses.
Preoperative serum TN is a significant indicator of postoperative complications in Danish OC patients and deserves to be validated in larger future studies.
尚未确定四连接蛋白（TN）与选定的生活方式因素（吸烟和饮酒）以及接受初次细胞减灭术的卵巢癌（OC）患者术后并发症发生率之间的关系。本研究的目的是检查 TN、吸烟和饮酒作为 OC 患者术后并发症指标的价值。
对 374 名接受初次细胞减灭术的 OC 患者进行了血清 TN 测量。此外，他们还报告了自己的吸烟和饮酒状况。使用逻辑回归分析进行单变量和多变量分析，发现了变量的预后价值。
在单变量分析中，TN 是 8 个变量中唯一显著预测术后并发症的变量（OR=0.55（95%CI：0.34-0.87），P=0.01）。术前高血清 TN 与术后并发症风险降低相关。多变量模型的逐步减少表明 TN 和组织学是唯一显著的协变量（TN，OR=0.51（95%CI：0.32-0.83），P=0.006；组织学，OR=1.70（95%CI：1.02-2.82），P=0.041）。TN 是唯一在单变量和多变量分析中均具有统计学意义的指标。
术前血清 TN 是丹麦 OC 患者术后并发症的一个重要指标，值得在未来更大的研究中进行验证。
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