The Gynecologic Clinic, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Obstet Gynecol Scand. 2010;89(2):190-8. doi: 10.3109/00016340903530936.
To evaluate the prognostic value of preoperative serum tetranectin (TN) in Danish ovarian cancer (OvCa) patients. Design. Population-based, multidisciplinary Danish case-control study of OvCa.
A total of 445 primary OvCa patients diagnosed at one of the gynecological departments in 18 regional hospitals around Denmark during the period 1994-1999.
Serum levels of TN were evaluated preoperatively and tested for possible association with prognosis.
Disease specific survival.
During the observation period (median 45.9 months, range 0.2-121) 278 OvCa-related deaths were seen. Univariate analysis of TN and CA125 demonstrated a significant association with survival using the Cox proportional hazards model, when stratified for adjuvant treatment (TN: p < 0.0001, hazard ratio = 0.44; 95% confidence interval 0.33-0.60 and CA125: p < 0.0001, hazard ratio = 1.19; 95% confidence interval 1.11-1.27). Disease specific survival curves for patients with tumors in the early stages showed no significant association with survival, neither for TN (p = 0.68) nor for CA125 (p = 0.07). For the stage III group, a significant association with survival was found for TN (p = 0.027), but not for CA125 (p = 0.37). Multivariate Cox analysis identified TN, age, residual tumor, International Federation of Gynecology and Obstetrics stage and grade but not serum CA125 as independent prognostic variables.
Preoperative serum TN is a useful prognostic indicator of advanced stage for patients with OvCa.
评估术前血清四旋蛋白（TN）在丹麦卵巢癌（OvCa）患者中的预后价值。设计：丹麦基于人群的多学科卵巢癌病例对照研究。参与者：共纳入 445 例于 1994-1999 年期间在丹麦 18 家地区医院的妇科部门诊断为原发性 OvCa 的患者。方法：评估术前血清 TN 水平，并检测其与预后的可能相关性。主要观察指标：疾病特异性生存。结果：在观察期间（中位数 45.9 个月，范围 0.2-121），观察到 278 例与 OvCa 相关的死亡。采用 Cox 比例风险模型对 TN 和 CA125 的单因素分析显示，在辅助治疗分层时与生存具有显著相关性（TN：p<0.0001，风险比=0.44；95%置信区间 0.33-0.60；CA125：p<0.0001，风险比=1.19；95%置信区间 1.11-1.27）。早期肿瘤患者的疾病特异性生存曲线与生存无显著相关性，TN（p=0.68）和 CA125（p=0.07）均如此。对于 III 期患者，TN 与生存具有显著相关性（p=0.027），但 CA125 则无相关性（p=0.37）。多因素 Cox 分析确定 TN、年龄、残留肿瘤、国际妇产科联合会分期和分级，但不是血清 CA125，是 OvCa 患者的独立预后变量。结论：术前血清 TN 是 OvCa 晚期患者的一种有用的预后指标。
