骨质疏松症的新疗法。

Newer therapies for osteoporosis.

机构信息

Department of Medicine, New York Medical College, New York, Valhalla, NY, USA.

出版信息

Am J Ther. 2010 Mar-Apr;17(2):197-200. doi: 10.1097/MJT.0b013e3181a6ee1c.

PMID:20305400

Abstract

The existing drugs for treatment of osteoporosis are limited in scope, tolerability, and efficacy. Newer osteoclast-targeted agents like inhibitors of receptor activator nuclear factor kappaB pathway, Cathepsin K, and integrins are under clinical development. Osteoblast-targeted therapies include the agents acting through the Wnt signaling pathway like sclerostin antagonists. The potential molecular targets and the emerging drugs for treatment of osteoporosis are discussed in this review.

摘要

现有的骨质疏松症治疗药物在范围、耐受性和疗效方面都受到限制。新型的破骨细胞靶向药物，如核因子κB 受体激活剂抑制剂、组织蛋白酶 K 和整合素，正在临床开发中。成骨细胞靶向治疗包括通过 Wnt 信号通路发挥作用的药物，如硬骨素拮抗剂。本文综述了骨质疏松症治疗的潜在分子靶点和新兴药物。