感染在哮喘发生和加重中的作用。
Role of infection in the development and exacerbation of asthma.
作者信息
Guilbert Theresa W, Denlinger Loren C
机构信息
Department of Pediatrics, University of Wisconsin School of Medicine & Public Health, 600 Highland Avenue, K4/944, CSC-4108, Madison, WI 53792, USA.
出版信息
Expert Rev Respir Med. 2010 Feb;4(1):71-83. doi: 10.1586/ers.09.60.
Abstract
Respiratory infections are associated with wheezing illnesses in all ages and may also impact the development and severity of asthma. Respiratory tract infections caused by viruses, Chlamydophila or Mycoplasma have been hypothesized to have significant roles in the pathogenesis of asthma. Progress is being made toward establishing the mechanisms by which these agents can cause acute wheezing and impact the pathophysiology of asthma. Host factors probably contribute to the risk of asthma inception and exacerbation, and these contributions may also vary with respect to early- versus adult-onset disease. This review discusses these various associations as they pertain to the development and exacerbation of asthma.
摘要
呼吸道感染在各年龄段均与喘息性疾病相关，并且可能也会影响哮喘的发生发展及严重程度。由病毒、嗜衣原体或支原体引起的呼吸道感染被认为在哮喘发病机制中起重要作用。在确定这些病原体导致急性喘息及影响哮喘病理生理学的机制方面正取得进展。宿主因素可能会增加哮喘起始和加重的风险，而且这些因素对早发型与成人型哮喘的影响可能也有所不同。本综述讨论了这些与哮喘发生发展及加重相关的各种关联。
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