锌摄入量与中国成年人高血糖风险：前瞻性江苏营养研究（JIN）。
Zinc intake and the risk of hyperglycemia among Chinese adults: the prospective Jiangsu Nutrition Study (JIN).
机构信息
Nutrition and Foodborne Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
出版信息
J Nutr Health Aging. 2010 Apr;14(4):332-5. doi: 10.1007/s12603-010-0075-0.
OBJECTIVE
To prospectively examine the associations between zinc intake, the zinc to heme iron ratio and the incidence of hyperglycemia in Chinese.
METHODS
We followed 1056 healthy adults aged 20 and older from 2002 to 2007. Dietary data were collected using 3-day food record and food frequency questionnaire. Hyperglycemia was defined as fasting plasma glucose > 5.6 mmol/l.
RESULTS
During the 5 years of follow-up, we documented 125 incident cases of hyperglycemia. Zinc intake alone was not associated with the risk of hyperglycemia. The zinc to heme iron ratio was inversely associated with the risk of hyperglycemia: odds ratios (OR, 95% CI) across increasing quartiles of the zinc to heme iron ratio were 1.00, 0.78(0.44-1.37), 0.40(0.19-0.83), and 0.21(0.08-0.54)(p for trend= 0.001). Adjustment for lifestyle covariates did not significantly change the associations.
CONCLUSIONS
This cohort study suggests that the zinc to heme iron intake ratio was significantly associated with a decreased risk of hyperglycemia in Chinese adults.
目的
前瞻性研究锌摄入量、锌与血红素铁的比值与中国人群发生高血糖的相关性。
方法
我们对 2002 年至 2007 年期间的 1056 名年龄在 20 岁及以上的健康成年人进行了随访。通过 3 天的食物记录和食物频率问卷收集饮食数据。高血糖的定义为空腹血糖>5.6mmol/L。
结果
在 5 年的随访期间，我们记录了 125 例高血糖新发病例。单独的锌摄入与高血糖风险无关。锌与血红素铁的比值与高血糖风险呈负相关：锌与血红素铁比值递增四分位数的比值比（OR，95%CI）分别为 1.00、0.78（0.44-1.37）、0.40（0.19-0.83）和 0.21（0.08-0.54）（趋势检验 P=0.001）。调整生活方式混杂因素后，相关性没有显著变化。
结论
这项队列研究表明，锌与血红素铁的摄入量比值与中国成年人发生高血糖的风险降低显著相关。
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