Chiba Yoshiro, Oka Kuniyuki, Saito Hajime, Nagayama Reizo, Murata Minoru, Mori Naoyoshi
Department of Cardiology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
Acta Cytol. 2010 Jan-Feb;54(1):79-81. doi: 10.1159/000324973.
Primay cardiac lymphoma is rare, and its diagnosis is not determined until autopsy.
A 49-year-old man presented with heart tamponade and atrioventricular block. Bloody pericardiac effusion showed a monotonous proliferation of atypical large mononuclear cells, which demonstrated a lambda light-chain monoclonality by the fluorescence-activated cell-sorter method and clonal rearrangement bands by Southern blot analysis of the IgH gene. Transvenous biopsy excised from the right atrial tumor was diagnosed as diffuse large B-cell lymphoma. He underwent chemotherapy and permanent pacemaker implantation and is alive and well.
Liquid cytology of cardiac effusion was very useful for rapid diagnosis, leading to a better prognosis.
原发性心脏淋巴瘤罕见，其诊断直至尸检时才能确定。
一名49岁男性出现心脏压塞和房室传导阻滞。血性心包积液显示非典型大单核细胞呈单一性增殖，通过荧光激活细胞分选法显示λ轻链单克隆性，通过IgH基因的Southern印迹分析显示克隆重排条带。经静脉从右心房肿瘤切除的活检组织被诊断为弥漫性大B细胞淋巴瘤。他接受了化疗并植入了永久性起搏器，目前存活且状况良好。
心脏积液的液体细胞学检查对快速诊断非常有用，可带来更好的预后。
