Nishikimi Kyoko, Habuka Nobuya, Okazima Yuko, Tate Shinichi, Nagai Yuichiro, Nakano Masayuki, Okawa Reiko, Shozu Makio
Department of Obstetrics and Gynecology, National Hospital Organization Chiba Medical Center, Chiba, Japan.
Acta Cytol. 2010 Jan-Feb;54(1):85-8. doi: 10.1159/000324975.
To report the cytologic characteristics of low grade endometrial stromal sarcoma with sex cord-like differentiation.
A 49-year-old woman presented with hypermenorrhea, menorrhalgia and anemia. With a diagnosis of degenerated leiomyoma of the uterus, simple total hysterectomy was conducted. Histologic examination revealed cells with ovoid to short, spindle-shaped nuclei resembling endometrial stromal cells proliferating in a space-occupying manner and compressing and partially infiltrating the myometrium. Some tumor cells were arranged in sex cord-like form, and hyalinization was observed in the center of the cord. Low grade endometrial stromal sarcoma with sex cord-like differentiation was diagnosed. Touch imprint cytologic examination of the tumor showed cells containing scanty cytoplasm and ovoid to spindle-shaped nuclei with little atypia; they were scattered individually, aggregated in clusters, or arranged in cord or glandular form. Hyaline-like substance was present in abundance. The histologic characteristics of the endometrial stromal sarcoma with sex cord-like differentiation were confirmed by touch imprint cytology of the tumor.
In this case of low grade endometrial stromal sarcoma with sex cord-like differentiation, cytologic examination revealed hyaline substance and tumor cells aligned in cord or glandular form.
报告具有性索样分化的低级别子宫内膜间质肉瘤的细胞学特征。
一名49岁女性，表现为月经过多、痛经和贫血。诊断为子宫平滑肌瘤退变，行单纯全子宫切除术。组织学检查显示，细胞呈卵圆形至短梭形核，类似子宫内膜间质细胞，呈占位性增殖，压迫并部分浸润肌层。部分肿瘤细胞呈性索样排列，索中央可见玻璃样变。诊断为具有性索样分化的低级别子宫内膜间质肉瘤。肿瘤的触摸印片细胞学检查显示，细胞胞质稀少，核呈卵圆形至梭形，异型性小；细胞单个散在、聚集成簇或呈条索状或腺管状排列。可见大量玻璃样物质。肿瘤的触摸印片细胞学检查证实了具有性索样分化的子宫内膜间质肉瘤的组织学特征。
在该例具有性索样分化的低级别子宫内膜间质肉瘤中，细胞学检查发现了玻璃样物质以及呈条索状或腺管状排列的肿瘤细胞。
