有机催化的对映选择性合成（2S,3R,4S）-4-羟基异亮氨酸及其立体异构体。
An Organocatalyzed enantioselective synthesis of (2S,3R,4S)-4-hydroxyisoleucine and its stereoisomers.
机构信息
Organic Division-III, Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
出版信息
J Org Chem. 2010 Apr 16;75(8):2745-7. doi: 10.1021/jo100233u.
PMID:20307090
Abstract
A concise enantioselective total synthesis of (2S,3R,4S)-4-hydroxyisoleucine and its stereoisomers is described. A key feature of this protocol is a catalytic enantioselective mannich reaction that is either anti- or syn-selective as genesis of chirality.
摘要
本文描述了一种简洁的对映选择性全合成（2S,3R,4S）-4-羟基异亮氨酸及其立体异构体的方法。该方案的一个关键特征是催化对映选择性曼尼希反应，该反应作为手性起源具有反式或顺式选择性。
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