一种新型4-羟基异亮氨酸合成中的两个关键手性中间体。
Two key chiral intermediates in a new 4-hydroxyisoleucine synthesis.
作者信息
Kassem T, Rolland V, Martinez J, Rolland M
机构信息
Laboratoire des Aminoacides, Peptides et Protéines, Université Montpellier I et II, Faculté de Pharmacie, UMR CNRS 5810, 15 Avenue Charles Flahault, 34060 Montpellier CEDEX 2, France.
出版信息
Acta Crystallogr C. 2000 Aug;56 ( Pt 8):1037-9. doi: 10.1107/s010827010000740x.
We present the crystal and molecular structure of two key compounds of a new synthesis strategy for isomers of natural (2S,3R, 4S)-4-hydroxyisoleucines, 2,3,5,6,7, 8-hexahydro-3-(1-hydroxy-1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(4), and 2,3,5,6,7, 8-hexahydro-3-(1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(3). A new optically pure chiral oxazinone auxiliary derived from (1R,2R, 5R)-2-hydroxypinan-3-one was used.
我们展示了一种用于天然（2S，3R，4S）-4-羟基异亮氨酸异构体新合成策略中两种关键化合物的晶体结构和分子结构，即2,3,5,6,7,8-六氢-3-(1-羟基-1-甲基-2-氧代丙基)-6,8-亚甲基-7,7,8a-三甲基-5H-1,4-苯并恶嗪-2-酮，C(16)H(23)NO(4)，以及2,3,5,6,7,8-六氢-3-(1-甲基-2-氧代丙基)-6,8-亚甲基-7,7,8a-三甲基-5H-1,4-苯并恶嗪-2-酮，C(16)H(23)NO(3)。使用了一种源自(1R,2R,5R)-2-羟基蒎烷-3-酮的新型光学纯手性恶嗪酮助剂。
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