将放射性标记的团簇封装在富勒烯笼内，(177)Lu(x)Lu((3-x))N@C(80)：一种与白细胞介素-13 结合的放射性标记金属富勒烯平台。
Encapsulation of a radiolabeled cluster inside a fullerene cage, (177)Lu(x)Lu((3-x))N@C(80): an interleukin-13-conjugated radiolabeled metallofullerene platform.
机构信息
Department of Radiology, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
出版信息
J Am Chem Soc. 2010 Apr 14;132(14):4980-1. doi: 10.1021/ja9093617.
Abstract
In this communication, we describe the successful encapsulation of (177)Lu into the endohedral metallofullerene (177)Lu(x)Lu(3-x)N@C(80) (x = 1-3) starting with (177)LuCl(3) in a modified quartz Kraschmer-Huffman electric generator. We demonstrate that the (177)Lu (beta-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.
摘要
在本通讯中，我们描述了（177）Lu 在内笼金属富勒烯（177）Lu（x）Lu（3-x）N@C（80）（x = 1-3）中的成功封装，起始物质为（177）LuCl（3），使用改良的石英 Kraschmer-Huffman 发电机。我们证明，在长达至少一半半衰期（6.7 天）的时间内，笼内的（177）Lu（β发射器）不会明显释放。我们还证明，该试剂可以与白介素-13 肽缀合，后者旨在靶向多形性胶质母细胞瘤中过表达的受体。这种纳米颗粒递药平台为广泛的放射治疗和放射诊断多模态应用提供了灵活性。
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