Lin Xiangtao, Tang Yuchun, Sun Bo, Hou Zhongyu, Meng Haiwei, Li Zhenping, Liu Qingwei, Liu Shuwei
Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, China.
Acta Radiol. 2010 Jun;51(5):549-54. doi: 10.3109/02841851003660065.
Most intracerebral hemorrhage (ICH) imaging studies focus on structural brain changes. Stereotactic neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) are helpful in the diagnosis of ICH, monitoring the subsequent recovery and investigating its functional mechanisms.
To explore the influence of the changes in cerebral glucose metabolism on perihematomal edema formation in an experimental cat model of ICH.
Forty-eight cats were divided into 1 sham operation group (6 cats) and 7 ICH model groups (42 cats)". The ICH model groups were injected with 1.0 ml autologous nonheparinized blood into their thalami using accurate stereotactic guidance apparatus. MRI and (18)F-fluorodeoxyglucose (FDG) PET/CT scans were acquired at 2, 6, 12, 24, 48, 72, and 120 h following the intervention. Pearson's correlation test was used to evaluate the association between T2-weighted signal intensity and the edema volume. Student's t test and q test were used to identify the times of significant temporal changes.
The volume of perilesional edema did not significantly increase from 2 h to 12 h after ICH, but then increased by 229.4% at 24 h, peaked (by 273.5%), and steadily decreased by 72 h. The FDG intensity in perihematomal edema tissues was markedly reduced 2 h after ICH on PET images, reached its lowest level at 12 h, and then steadily increased at 24 h and 48 h. The changes of standard absorption value (SUV) in perihematomal edema were consistent with those of FDG intensity.
Perihematomal glucose metabolism abnormalities have a close relationship with the formation of vasogenic edema. Furthermore, abnormal glucose metabolism may impair capillary integrity and increase blood-brain barrier permeability.
大多数脑出血（ICH）影像学研究聚焦于脑结构变化。立体定向神经成像技术，如磁共振成像（MRI）和正电子发射断层扫描/计算机断层扫描（PET/CT），有助于脑出血的诊断、监测后续恢复情况并探究其功能机制。
在脑出血实验猫模型中探讨脑葡萄糖代谢变化对血肿周围水肿形成的影响。
48只猫分为1个假手术组（6只猫）和7个脑出血模型组（42只猫）。使用精确的立体定向引导装置向脑出血模型组猫的丘脑注射1.0 ml自体非肝素化血液。干预后2、6、12、24、48、72和120小时进行MRI和（18）F-氟脱氧葡萄糖（FDG）PET/CT扫描。采用Pearson相关检验评估T2加权信号强度与水肿体积之间的关联。采用Student's t检验和q检验确定显著的时间变化点。
脑出血后2小时至12小时，病灶周围水肿体积无明显增加，但在24小时时增加了229.4%，达到峰值（增加273.5%），并在72小时时稳步下降。PET图像显示，脑出血后2小时血肿周围水肿组织中的FDG强度明显降低，在12小时达到最低水平，然后在24小时和48小时稳步增加。血肿周围水肿的标准摄取值（SUV）变化与FDG强度变化一致。
血肿周围葡萄糖代谢异常与血管源性水肿的形成密切相关。此外，葡萄糖代谢异常可能损害毛细血管完整性并增加血脑屏障通透性。
