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一名新诊断为科斯特洛综合征的儿童在接受生长激素治疗时，肥厚型心肌病病情逐渐恶化。

Progressively worsening hypertrophic cardiomyopathy in a child with newly diagnosed Costello syndrome while receiving growth hormone therapy.

作者信息

Kobayashi Daisuke, Cook Amanda L, Williams Derek A

机构信息

Division of Pediatric Cardiology, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

出版信息

Cardiol Young. 2010 Aug;20(4):459-61. doi: 10.1017/S1047951110000260. Epub 2010 Mar 22.

DOI:10.1017/S1047951110000260
PMID:20307337
Abstract

We describe a 6-year-old boy with newly diagnosed Costello syndrome after the diagnosis of severe hypertrophic cardiomyopathy. His neonatal asymmetric septal cardiomyopathy resolved by 9 months of age but reappeared at 6 years of age. This report highlights two important concepts: the association of genetic syndromes with hypertrophic cardiomyopathy and the possibility of worsening severity of hypertrophic cardiomyopathy linked to growth hormone therapy.

摘要

我们描述了一名6岁男孩，在被诊断出患有严重肥厚型心肌病后，新确诊为科斯特洛综合征。他的新生儿期非对称性室间隔心肌病在9个月大时得到缓解，但在6岁时再次出现。本报告强调了两个重要概念：遗传综合征与肥厚型心肌病的关联，以及与生长激素治疗相关的肥厚型心肌病严重程度恶化的可能性。

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Progressively worsening hypertrophic cardiomyopathy in a child with newly diagnosed Costello syndrome while receiving growth hormone therapy.一名新诊断为科斯特洛综合征的儿童在接受生长激素治疗时，肥厚型心肌病病情逐渐恶化。
Cardiol Young. 2010 Aug;20(4):459-61. doi: 10.1017/S1047951110000260. Epub 2010 Mar 22.
2
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引用本文的文献

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Inside the Noonan "universe": Literature review on growth, GH/IGF axis and rhGH treatment: Facts and concerns.努南“综合征”的相关研究：生长、GH/IGF 轴及 rhGH 治疗的文献回顾：事实与关注。
Front Endocrinol (Lausanne). 2022 Aug 18;13:951331. doi: 10.3389/fendo.2022.951331. eCollection 2022.
2
Recombinant growth hormone therapy in a girl with Costello syndrome: a 4-year observation.一名患有科斯特洛综合征女孩的重组生长激素治疗：4年观察
Ital J Pediatr. 2016 Jan 26;42:10. doi: 10.1186/s13052-015-0209-4.
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Pediatric cardiomyopathies: causes, epidemiology, clinical course, preventive strategies and therapies.
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Future Cardiol. 2013 Nov;9(6):817-48. doi: 10.2217/fca.13.66.