Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, NC 27599, USA.
J Anxiety Disord. 2010 May;24(4):423-32. doi: 10.1016/j.janxdis.2010.02.007. Epub 2010 Feb 20.
The current study assessed the incremental prediction of anxiety sensitivity (AS) in both taxonic (categorical) and dimensional representations at various time points before and after a single vital capacity inhalation of a 35% CO(2), 65% balanced O(2) gas mixture. Participants were 128 young adults screened for a history of panic attacks. By controlling for traitwise factors including state anxiety and testing both categorical and continuous conceptualizations of the AS construct at various timepoints, the present report was able to evaluate the temporal and structural dynamics of AS in relation to fearful responding to the challenge. Relevant variables were evaluated in a hierarchical linear regression framework, and it was found that a continuous conceptualization of AS provided incremental predictive validity above and beyond trait anxiety immediately post-challenge, while a categorical representation of AS was equivalent to a continuous model of AS at post-challenge but outperformed a continuous model at follow-up. These data provide basic but important evidence suggesting that AS is uniquely associated with anxious responding to a 35% CO(2) challenge, and that categorical representations of AS should be considered in biological challenge studies.
本研究评估了在单次肺活量吸入 35%CO₂和 65%平衡 O₂混合气体前后的不同时间点，焦虑敏感（AS）的分类（类别）和维度（连续）表示对焦虑的增量预测。参与者是 128 名年轻成年人，他们被筛选出有恐慌发作史。通过控制特质因素，包括状态焦虑，并在不同时间点测试 AS 结构的分类和连续概念，本报告能够评估 AS 与对挑战的恐惧反应的时间和结构动态。在分层线性回归框架中评估了相关变量，发现 AS 的连续概念在挑战后立即提供了超越特质焦虑的增量预测有效性，而 AS 的分类表示在挑战后与 AS 的连续模型相当，但在随访时优于连续模型。这些数据提供了基本但重要的证据，表明 AS 与对 35%CO₂挑战的焦虑反应独特相关，并且在生物挑战研究中应考虑 AS 的分类表示。
