Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital, PO Box 220, FI-00029 HUCH, Helsinki, Finland.
Oral Oncol. 2010 May;46(5):369-72. doi: 10.1016/j.oraloncology.2010.02.012. Epub 2010 Mar 21.
Chemoradiotherapy (CRT) of head and neck squamous cell carcinoma (HNSCC) is often accompanied by severe mucosal reactions. We have recently shown that the single nucleotide polymorphism (SNP) rs1982073 of the TGFbeta1 gene (TGFB1) is associated with the survival of HNSCC patients who have undergone CRT. In order to evaluate possible mechanisms mediating this, we investigated if the TGFB1 polymorphism was associated with the severity of mucositis induced by CRT. Peripheral blood DNA of 34 HNSCC patients who had undergone CRT was genotyped for the SNP rs1982073 of the TGFB1. Mucositis was graded according to acute toxicity criteria of radiation therapy oncology group (RTOG). The mean follow-up time was 48 months (range, 4-115 months). We did not find a significant association between the TGFB1 polymorphism and the degree of acute mucositis (OD=2.65; 95% CI 0.50-13.89; p=0.25). The degree of acute mucositis was not connected to disease-free survival (p=0.35). However, the TGFB1 polymorphism was associated with survival irrespective of the degree of mucositis (HR=3.23; 95% CI 1.19-8.77; p=0.02).
头颈部鳞状细胞癌 (HNSCC) 的化放疗常伴有严重的黏膜反应。我们最近发现 TGFbeta1 基因 (TGFB1) 的单核苷酸多态性 (SNP) rs1982073 与接受 CRT 的 HNSCC 患者的生存有关。为了评估可能介导这种情况的机制,我们研究了 TGFB1 多态性是否与 CRT 诱导的黏膜炎严重程度有关。对 34 例接受 CRT 的 HNSCC 患者的外周血 DNA 进行了 TGFB1 的 SNP rs1982073 基因分型。根据放射肿瘤学组 (RTOG) 的急性毒性标准对黏膜炎进行分级。平均随访时间为 48 个月(范围为 4-115 个月)。我们没有发现 TGFB1 多态性与急性黏膜炎程度之间存在显著相关性(OD=2.65;95%CI 0.50-13.89;p=0.25)。急性黏膜炎程度与无病生存率无关(p=0.35)。然而,TGFB1 多态性与生存率有关,而与黏膜炎程度无关(HR=3.23;95%CI 1.19-8.77;p=0.02)。