CSP-1 的特性研究，一种新型的可扩展谱β-内酰胺酶，由临床分离的 Capnocytophaga sputigena 产生。
Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena.
机构信息
Service de Bactériologie, Centre Hospitalo-Universitaire d'Amiens, Hôpital Nord, Faculté de Médecine d'Amiens, Université de Picardie Jules Verne, Amiens, France.
出版信息
Antimicrob Agents Chemother. 2010 May;54(5):2231-4. doi: 10.1128/AAC.00791-09. Epub 2010 Mar 22.
Abstract
The Capnocytophaga sputigena isolate NOR, responsible for septicemia, was resistant to amoxicillin and narrow-spectrum cephalosporins. In a cloning experiment, a new gene, bla(CSP-1), was identified; this gene encodes a novel extended-spectrum beta-lactamase (ESBL) that shares only 52% and 49% identities with the CME-1 and VEB-1 beta-lactamases, respectively. The G+C content of this gene, its genetic environment, the absence of conjugation transfer, and its detection in two reference strains suggested that it was an intrinsic resistance gene located on the chromosome.
摘要
分离自导致败血症的斯氏片球菌（Capnocytophaga sputigena）的 NOR 株对阿莫西林和窄谱头孢菌素具有耐药性。在克隆实验中，鉴定出一个新基因 bla(CSP-1)，该基因编码一种新型的超广谱β-内酰胺酶（ESBL），与 CME-1 和 VEB-1 内酰胺酶的分别只有 52%和 49%的同源性。该基因的 G+C 含量、遗传环境、缺乏接合转移以及在两个参考菌株中的检出提示其是位于染色体上的固有耐药基因。
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