Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
AJR Am J Roentgenol. 2010 Apr;194(4):903-8. doi: 10.2214/AJR.09.3460.
The objective of our study was to investigate the effect on aortic enhancement of contrast material volumes adjusted for a patient's body surface area (BSA) at CT angiography (CTA).
A 64-MDCT scanner was used to perform CTA of the whole aorta in 89 patients (mean age, 68.7 years) with confirmed or suspected aortoiliac disease. The patients were divided into groups: a body weight (BW) group (n = 45) and a BSA (n = 44) group. The contrast dose was 360 mg I/kg BW in the BW group and 12,753 mg I/m(2) BSA in the BSA group. Because the average BW of Japanese adults is approximately 60 kg, the contrast dose in the two protocols was identical in patients weighing 60 kg. We compared aortic enhancement achieved with the two protocols using the two-tailed Student's t test, and we used the generalized linear model to analyze the effect of patient age, sex, and BW on aortic enhancement in each protocol group.
The mean aortic enhancement in the BW and BSA groups was 324.2 and 311.7 HU, respectively; the difference was not significant (p = 0.26). In the BW group, BW had a statistically significant effect on aortic enhancement (p < 0.01), whereas neither patient age nor sex did (p = 0.08 and 0.07, respectively). In the BSA group, the age, sex, BW, and BW by sex had no statistically significant effect on aortic enhancement (p = 0.33, 023, 0.10, and 0.16, respectively).
Under the BSA protocol, aortic enhancement tended to be consistent and adequate regardless of patient BW.
本研究旨在探讨体表面积（BSA）调整的对比剂用量对 CT 血管造影（CTA）主动脉增强的影响。
使用 64 排 MDCT 扫描仪对 89 例经证实或疑似主髂动脉疾病的患者行全主动脉 CTA 检查。患者分为体重（BW）组（n = 45）和 BSA 组（n = 44）。BW 组对比剂剂量为 360 mg I/kg BW，BSA 组为 12753 mg I/m2 BSA。由于日本成年人的平均体重约为 60kg，因此在体重为 60kg 的患者中，两种方案的对比剂剂量相同。我们使用双尾学生 t 检验比较两种方案的主动脉增强效果，并使用广义线性模型分析两种方案中患者年龄、性别和 BW 对主动脉增强的影响。
BW 组和 BSA 组的平均主动脉增强分别为 324.2 和 311.7 HU，差异无统计学意义（p = 0.26）。在 BW 组，BW 对主动脉增强有统计学显著影响（p < 0.01），而患者年龄和性别无统计学显著影响（p = 0.08 和 0.07）。在 BSA 组，年龄、性别、BW 和 BW 与性别无统计学显著影响主动脉增强（p = 0.33、0.23、0.10 和 0.16）。
在 BSA 方案下，无论患者 BW 如何，主动脉增强都趋于一致且充足。
